About: Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High‐Throughput Helicase Activity Assay Based on Graphene Oxide

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About: Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High‐Throughput Helicase Activity Assay Based on Graphene Oxide Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High‐Throughput Helicase Activity Assay Based on Graphene Oxide
Creator	Kim, Dong-Eun Min, Dal-Hee Jang, Hongje Ryoo, Soo-Ryoon Kim, H Han, S Han, Sang Jang, H Choi, B.-S Choi, Byong-Seok Kim, D.-E Kim, Henna Kim, Y.-K Kim, Young-Kwan Min, D.-H Ryoo, S.-R Yoon, S Yoon, Soojin
Source	Medline; PMC
abstract	A GO‐to solution: A simple graphene oxide (GO)‐based assay to screen for selective inhibitors of a hepatitis C virus (HCV) helicase along with inhibitors of a severe acute respiratory syndrome coronavirus (SARS CoV) helicase was tested (see scheme). A single screen found five inhibitors highly selective for the HCV helicase orthologous to the SARS CoV helicase. Some of these hits were validated using the same GO‐based assay.[Image: see text]
has issue date	2013-02-18(xsd:dateTime)
bibo:doi	10.1002/anie.201209222
bibo:pmid	23355441
has license	no-cc
sha1sum (hex)	6d106d94ce15d0f5edd23e522f40e44535be2545
schema:url	https://doi.org/10.1002/anie.201209222
resource representing a document's title	Discovery of Hepatitis C Virus NS3 Helicase Inhibitors by a Multiplexed, High‐Throughput Helicase Activity Assay Based on Graphene Oxide
has PubMed Central identifier	PMC7159783
has PubMed identifier	23355441
schema:publication	Angew Chem Int Ed Engl
resource representing a document's body	covid:6d106d94ce15d0f5edd23e522f40e44535be2545#body_text
is schema:about of	named entity 'leads' named entity 'HCV' named entity 'cirrhosis' named entity 'Graphene' named entity 'Drug Discovery' named entity 'clearing' named entity 'HCV' named entity 'Helicase' named entity 'hepatocarcinoma' named entity 'virus' named entity 'HCV' named entity 'standard treatment' named entity 'fatigue' named entity 'hepatitis' named entity 'infection' named entity 'inhibitor' named entity 'luciferase' named entity 'Cy3' named entity 'HCV' named entity 'helicases' named entity 'drug candidate' named entity 'NS3' named entity 'helicase' named entity 'NTPs' named entity 'poor activity' named entity 'Cy5' named entity 'HCV' named entity 'biosensors' named entity 'false positive' named entity 'antiviral drugs' named entity 'RNA replication' named entity 'helicases' named entity 'high-throughput screening' named entity 'structure-activity relationship' named entity 'NS3' named entity 'HCV' named entity 'water-dispersible' named entity 'serine protease inhibitors' named entity 'helicases' named entity 'single-stranded' named entity 'caspases' named entity 'helicase' named entity 'helicase' named entity 'virus replication' named entity 'helicases' named entity 'graphene oxide' named entity 'NS3' named entity 'Dose-dependent' named entity 'hepatitis C virus' named entity 'HCV' named entity 'fatigue' named entity 'NS3' named entity 'Huh-7' named entity 'SARS CoV' named entity 'NS3' named entity 'helicase' named entity 'dose-response' named entity 'chemical structure' named entity 'SARS CoV' named entity '49.3' named entity 'activity assays' named entity 'NS3' named entity 'replicon' named entity 'NS3'

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