About: The pathogenesis of inflammatory disease: Surgical shock and multiple system organ failure

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The pathogenesis of inflammatory disease: Surgical shock and multiple system organ failure
Creator	Parke, A Parke, D
Source	PMC
abstract	Chronic inflammatory disease, embracing rheumatoid arthritis (RA), inflammatory bowel disease (IBD), hepatitis, asthma, atherosclerosis, multiple system organ failure (MSOF), etc., is mediated by reactive oxygen species (ROS). These ROS originate from activated neutrophils in infections and in immune and autoimmune reactions, from tissue deposits of ferritin, and from futile cycling of cytochrome P450 (CYP) following exposure to persistent chemicals, and may be perpetuated by the actions of complement, cytokines and eicosanoids. Acute inflammation is normally arrested by removal of ROS by tissue glutathione (GSH) and the antioxidant vitamins, A, C and E, all of which are regenerated by NADH and NADPH. Failure of this antioxidant defence system can lead to oxidative stress and to chronic inflammatory disease, including surgical shock and MSOF. The roles of oxidative stress and microcirculatory arrest in promoting MSOF, and of GSH, the antioxidant defence system, and fibronectin in preventing this, are reviewed in the light of recent experimental studies of surgical shock, including fasting, anaesthesia, hepatic ischaemia and reperfusion.
has issue date	1995-01-01(xsd:dateTime)
bibo:doi	10.1007/bf02674919
has license	no-cc
sha1sum (hex)	6d1d15fd6108b380cd13259c64949ab5e801562b
schema:url	https://doi.org/10.1007/bf02674919
resource representing a document's title	The pathogenesis of inflammatory disease: Surgical shock and multiple system organ failure
has PubMed Central identifier	PMC7101736
schema:publication	Inflammopharmacology
resource representing a document's body	covid:6d1d15fd6108b380cd13259c64949ab5e801562b#body_text
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