About: Protein-protein interactions of human viruses

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Protein-protein interactions of human viruses
Creator	Bae, Eunhae Devkota, Prajwal Goodacre, Norman Uetz, Peter Wuchty, Stefan
Source	Elsevier; Medline; PMC
abstract	Abstract Viruses infect their human hosts by a series of interactions between viral and host proteins, indicating that detailed knowledge of such virus-host interaction interfaces are critical for our understanding of viral infection mechanisms, disease etiology and the development of new drugs. In this review, we primarily survey human host-virus interaction data that are available from public databases following the standardized PSI-MS format. Notably, available host-virus protein interaction information is strongly biased toward a small number of virus families including herpesviridae, papillomaviridae, orthomyxoviridae and retroviridae. While we explore the reliability and relevance of these protein interactions we also survey the current knowledge about viruses functional and topological targets. Furthermore, we assess emerging frontiers of host-virus protein interaction research, focusing on protein interaction interfaces of hosts that are infected by different viruses and viruses that infect multiple hosts. Finally, we cover the current status of research that investigates the relationships of virus-targeted host proteins to other comorbidities as well as the influence of host-virus protein interactions on human metabolism.
has issue date	2020-03-31(xsd:dateTime)
bibo:doi	10.1016/j.semcdb.2018.07.018
bibo:pmid	30031213
has license	els-covid
sha1sum (hex)	6d2e8e37b270fd1a943d27d9d6014237e5f31d56
schema:url	https://doi.org/10.1016/j.semcdb.2018.07.018
resource representing a document's title	Protein-protein interactions of human viruses
has PubMed Central identifier	PMC7102568
has PubMed identifier	30031213
schema:publication	Seminars in Cell & Developmental Biology
resource representing a document's body	covid:6d2e8e37b270fd1a943d27d9d6014237e5f31d56#body_text
is schema:about of	named entity 'viral infection' named entity 'viruses' named entity 'interaction' named entity 'proteins' named entity 'disease' named entity 'Protein-protein interactions' named entity 'PSI' named entity 'INTERACTIONS' named entity 'DISEASE ETIOLOGY' named entity 'NEW' named entity 'METABOLISM' named entity 'PAPILLOMAVIRIDAE' named entity 'VIRUSES' named entity 'VIRUS-HOST INTERACTION' named entity 'INCLUDING' named entity 'PROTEIN INTERACTIONS' named entity 'COMORBIDITIES' named entity 'INFECTED' named entity 'HOSTS' named entity 'SURVEY' named entity 'SMALL' named entity 'DEVELOPMENT' named entity 'AVAILABLE' named entity 'ORTHOMYXOVIRIDAE' named entity 'DATABASES' named entity 'PROTEIN INTERACTION' named entity 'REVIEW' named entity 'VIRUS' named entity 'ABOUT' named entity 'CRITICAL' named entity 'ASSESS' named entity 'RELIABILITY' named entity 'VIRAL AND' named entity 'THESE' named entity 'MULTIPLE' named entity 'BIASED' named entity 'VIRUS PROTEIN' named entity 'INFORMATION' named entity 'COVER' named entity 'OUR' named entity 'TARGETED' named entity 'TARGETS' named entity 'INVESTIGATES' named entity 'DETAILED' named entity 'RESEARCH' named entity 'PROTEIN-PROTEIN INTERACTIONS' named entity 'HUMAN' named entity 'VIRUSES' named entity 'FOCUSING' named entity 'VIRAL INFECTION' named entity 'PROTEINS' named entity 'FOLLOWING' named entity 'DRUGS' named entity 'INDICATING' named entity 'RETROVIRIDAE' named entity 'SERIES' named entity 'STATUS' named entity 'HOST' named entity 'CURRENT' named entity 'FUNCTIONAL' named entity 'INTERACTION DATA' named entity 'MECHANISMS' named entity 'HERPESVIRIDAE' named entity 'KNOWLEDGE' named entity 'PUBLIC' named entity 'UNDERSTANDING' named entity 'THEIR' named entity 'NUMBER OF' named entity 'INFLUENCE' named entity 'DIFFERENT' named entity 'RELATIONSHIPS' named entity 'RELEVANCE' named entity 'FORMAT' named entity 'INFECT' named entity 'HUMAN' named entity 'FAMILIES' covid:arg/6d2e8e37b270fd1a943d27d9d6014237e5f31d56

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