About: Duration of postviral airway hyperresponsiveness in children with asthma: Effect of atopy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Duration of postviral airway hyperresponsiveness in children with asthma: Effect of atopy
Creator	Bossios, Apostolos Xepapadaki, Paraskevi Papadopoulos, Nikolaos Saxoni-Papageorgiou, Photini Manousakas, Theodoros Manoussakis, Emmanuel Athens, Phd
source	Elsevier; Medline; PMC
abstract	Background Respiratory viruses induce asthma exacerbations and airway hyperresponsiveness (AHR). Atopy is an important risk factor for asthma persistence. Objective We sought to evaluate whether atopy is a risk factor for prolonged AHR after upper respiratory tract infections (URIs). Methods Twenty-five children (13 atopic and 12 nonatopic children) with intermittent virus-induced asthma were studied. Clinical evaluation, skin prick tests, methacholine bronchoprovocation, questionnaires, and a nasal wash specimen were obtained at baseline. For 9 months, subjects completed diary cards with respiratory symptoms. During their first reported cold, a nasal wash specimen was obtained. Methacholine provocation was performed 10 days and 5, 7, 9, and 11 weeks later. In case a new cold developed, the provocation schedule was followed from the beginning. Results Viruses were detected in 17 (68%) of 25 patients during their first cold, with rhinovirus being most commonly identified (82%). AHR increased significantly 10 days after the URI, equally in both groups (P =.67), and remained so up to the fifth week. Duration of AHR in subjects experiencing a single URI ranged from 5 to 11 weeks, without a significant difference between groups. In the duration of the study, atopic children experienced more colds and asthma exacerbations than nonatopic children. Thus for duration of AHR, significant prolongation was noted in the atopic group when assessed cumulatively. Conclusion In asthmatic children the duration of AHR after a single natural cold is 5 to 11 weeks. However, an increased rate of symptomatic cold and asthma episodes in atopic children is associated with considerable cumulative prolongation of AHR, which might help explain the role of atopy as a risk factor for asthma persistence.
has issue date	2005-08-31(xsd:dateTime)
bibo:doi	10.1016/j.jaci.2005.04.007
bibo:pmid	16083783
has license	els-covid
sha1sum (hex)	6d340108379459c777ab70dd7483ab6135c8281f
schema:url	https://doi.org/10.1016/j.jaci.2005.04.007
resource representing a document's title	Duration of postviral airway hyperresponsiveness in children with asthma: Effect of atopy
has PubMed Central identifier	PMC7172284
has PubMed identifier	16083783
schema:publication	Journal of Allergy and Clinical Immunology
resource representing a document's body	covid:6d340108379459c777ab70dd7483ab6135c8281f#body_text
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