About: Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses

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About: Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses Goto Sponge NotDistinct Permalink

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses
Creator	Yang, Kun Al-Ghonaium, Abdulaziz Al-Hajjar, Sami Casanova, Jean-Laurent Casrouge, Armanda Chapel, Helen Davidson, Donald Eidenschenk, Céline Garty, Ben-Zion Geissmann, Frédéric Jouanguy, Emmanuelle Ku, Cheng-Lung Lebon, Pierre Li, Xiaoxia Maródi, László Ozinsky, Adrian Picard, Capucine Plancoulaine, Sabine Puel, Anne Rodriguez-Gallego, Carlos Roifman, Chaim Senechal, Brigitte Speert, David Zhang, Shenying Barrat, Franck Coffman, Robert Miller, Richard Von Bernuth, Horst
Source	Elsevier; Medline; PMC
abstract	Five TLRs are thought to play an important role in antiviral immunity, sensing viral products and inducing IFN-α/β and -λ. Surprisingly, patients with a defect of IRAK-4, a critical kinase downstream from TLRs, are resistant to common viruses. We show here that IFN-α/β and -λ induction via TLR-7, TLR-8, and TLR-9 was abolished in IRAK-4-deficient blood cells. In contrast, IFN-α/β and -λ were induced normally by TLR-3 and TLR-4 agonists. Moreover, IFN-β and -λ were normally induced by TLR-3 agonists and viruses in IRAK-4-deficient fibroblasts. We further show that IFN-α/β and -λ production in response to 9 of 11 viruses tested was normal or weakly affected in IRAK-4-deficient blood cells. Thus, IRAK-4-deficient patients may control viral infections by TLR-3- and TLR-4-dependent and/or TLR-independent production of IFNs. The TLR-7-, TLR-8-, and TLR-9-dependent induction of IFN-α/β and -λ is strictly IRAK-4 dependent and paradoxically redundant for protective immunity to most viruses in humans.
has issue date	2005-11-15(xsd:dateTime)
bibo:doi	10.1016/j.immuni.2005.09.016
bibo:pmid	16286015
has license	no-cc
sha1sum (hex)	6d3c43c36a9e8f1dbb225c0488ac5b65164663c6
schema:url	https://doi.org/10.1016/j.immuni.2005.09.016
resource representing a document's title	Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses
has PubMed Central identifier	PMC7111074
has PubMed identifier	16286015
schema:publication	Immunity
resource representing a document's body	covid:6d3c43c36a9e8f1dbb225c0488ac5b65164663c6#body_text
is schema:about of	named entity 'BLOOD CELLS' named entity 'MEDIATED' named entity 'Immunity' named entity 'TLR' named entity 'IRAK-4' named entity 'DATA HUMAN' named entity 'PROTECTIVE IMMUNITY' named entity 'IFN' named entity 'INDUCTION' named entity 'DEPENDENT' named entity 'AGONISTS' named entity 'SUPPLEMENTAL' named entity 'RESULTS' named entity 'IN BLOOD' named entity 'REDUNDANT' named entity 'VIRUSES' named entity 'TLR' named entity 'Data' named entity 'Human' named entity 'IFN-α/β' named entity 'Agonists' named entity 'asymptomatic' named entity 'pathogens' named entity 'LPS' named entity 'Streptococcus pneumoniae' named entity 'RNA' named entity 'Monocytes' named entity 'pneumococcal meningitis' named entity 'influenza virus' named entity 'viruses' named entity 'Pyogenic' named entity 'Canadian' named entity 'Streptococcus milleri' named entity 'measles, mumps' named entity 'HSV-1' named entity 'vaccine' named entity 'parvovirus B19' named entity 'RPMI' named entity 'IgG' named entity 'staphylococcal' named entity 'LPS' named entity 'viruses' named entity 'IFN' named entity 'IRAK' named entity 'human metapneumovirus' named entity 'Sendai virus' named entity 'Shigella sonnei' named entity 'enterovirus' named entity 'viral infection' named entity 'Sindbis virus' named entity 'monocytes' named entity 'mumps virus' named entity 'staphylococcal' named entity 'MMR'

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