About: Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo‐electron microscopy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo‐electron microscopy
Creator	Rottier, Peter Veesler, David Walls, Alexandra Bosch, Jan Dimaio, Frank Rey, Felix Brandon Frenz, † Tortorici, †
Source	Medline; PMC
abstract	The tremendous pandemic potential of coronaviruses was demonstrated twice in the last 15 years by two global outbreaks of deadly pneumonia. Entry of coronaviruses into cells is mediated by the transmembrane spike glycoprotein S, which forms a trimer carrying receptor‐binding and membrane fusion functions. Despite their biomedical importance, coronavirus S glycoproteins have proven difficult targets for structural characterization, precluding high‐resolution studies of the biologically relevant trimer. Recent technological developments in single particle cryo‐electron microscopy allowed us to determine the first structure of a coronavirus S glycoprotein trimer which provided a framework to understand the mechanisms of viral entry and suggested potential inhibition strategies for this family of viruses. Here, we describe the key factors that enabled this breakthrough.
has issue date	2016-10-18(xsd:dateTime)
bibo:doi	10.1002/pro.3048
bibo:pmid	27667334
has license	bronze-oa
sha1sum (hex)	6d3dd61e2046be5eb8a1cac9fa380482544eb31e
schema:url	https://doi.org/10.1002/pro.3048
resource representing a document's title	Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo‐electron microscopy
has PubMed Central identifier	PMC5192993
has PubMed identifier	27667334
schema:publication	Protein Science
resource representing a document's body	covid:6d3dd61e2046be5eb8a1cac9fa380482544eb31e#body_text
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