About: A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia.

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About: A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia. Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia.
Creator	Alberici, Federico Bossini, Nicola Delbarba, Elisa Econimo, Laura Gaggiotti, Mario Maffei, Camilla Manenti, Chiara Pola, Alessandra Possenti, Stefano Scolari, Francesco Valerio, Francesca Affatato, Stefania Moscato, Marianna Zambetti, Nicole Venturini, Margherita
Source	Elsevier; Medline; PMC
abstract	Abstract The outcome of SARS-CoV2 infection in patients who have received a kidney allograft and are being treated with immunosuppression is unclear. We describe 20 kidney transplant recipients (median age 59 years [inter quartile range 51-64 years], median age of transplant 13 years [9-20 years], baseline eGFR 36.5 [23-47.5]) with SARS-CoV2 induced pneumonia. At admission, all had immunosuppression withdrawn and were started on methylprednisolone 16 mg/day, all but one was commenced on antiviral therapy and hydroxychloroquine with doses adjusted for kidney function. At baseline, all patients presented fever but only one complained of difficulty in breathing. Half of patients showed chest radiographic evidence of bilateral infiltrates while the other half showed unilateral changes or no infiltrates. During a median follow-up of seven days, 87% experienced a radiological progression and among those 73% required escalation of oxygen therapy. Six patients developed acute kidney injury with one requiring hemodialysis. Six of 12 patients were treated with tocilizumab, a humanized monoclonal antibody to the IL-6 receptor. Overall, five kidney transplant recipients died after a median period of 15 days [15-19] from symptom onset. These preliminary findings describe a rapid clinical deterioration associated with chest radiographic deterioration and escalating oxygen requirement in renal transplant recipients with SARS-Cov2 pneumonia. Thus, in this limited cohort of long-term kidney transplant patients, SARS-CoV-2 induced pneumonia is characterized by high risk of progression and significant mortality.
has issue date	2020-04-09(xsd:dateTime)
bibo:doi	10.1016/j.kint.2020.04.002
bibo:pmid	32354634
has license	els-covid
sha1sum (hex)	6d4c6b9d8663d1865ebc23f4b2b8d86a1ec3f160
schema:url	https://doi.org/10.1016/j.kint.2020.04.002
resource representing a document's title	A single center observational study of the clinical characteristics and short-term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia.
has PubMed Central identifier	PMC7142691
has PubMed identifier	32354634
schema:publication	Kidney Int
resource representing a document's body	covid:6d4c6b9d8663d1865ebc23f4b2b8d86a1ec3f160#body_text
is schema:about of	named entity 'patients' named entity 'single center' named entity 'pneumonia' named entity 'clinical characteristics' named entity 'COVID -19' named entity 'kidney transplant' named entity 'Single center' named entity 'kidney transplant' named entity 'infection' named entity 'Antibiotics' named entity 'methylprednisolone' named entity 'symptom' named entity 'methylprednisolone' named entity 'follow-up' named entity 'symptom' named entity 'pneumonia' named entity 'SARS-CoV2' named entity 'mortality rate' named entity 'transplantation surgery' named entity 'glycopeptides' named entity 'allograft' named entity 'glucocorticoids' named entity 'ethical approval' named entity '2.1' named entity 'inflammatory cytokines' named entity 'oxygen' named entity 'lopinavir/ritonavir' named entity '1.2' named entity 'prednisone' named entity 'oxygen' named entity 'oxygen' named entity 'SARS-CoV2' named entity 'IL-6 receptor' named entity 'antiviral therapy' named entity 'Italian' named entity 'vomiting' named entity '5.5' named entity 'kidney transplant' named entity 'pneumonia' named entity 'creatinine' named entity 'viral load' named entity 'SARS-CoV2' named entity 'cardiovascular diseases' named entity 'chronic respiratory diseases' named entity 'COVID-19 epidemic' named entity 'kidney transplant' named entity 'immunosuppression' named entity 'radiographic' named entity 'toxicity' named entity 'cephalosporins' named entity 'acute kidney injury' named entity 'tocilizumab' named entity 'nausea' named entity 'fever' named entity 'kidney transplant' named entity 'NIV' named entity 'pneumonia' named entity 'tocilizumab' named entity 'metabolism' named entity 'QTc' named entity 'carbapenems' named entity 'kidney function' named entity 'comorbidities' named entity 'health systems' named entity 'antiviral therapy' named entity 'follow-up' named entity 'methylprednisolone'

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