About: Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis
Creator	Pomar, Léo Carolina, Ana Navegantes De Araújo, Wildo Nerurkar, Vivek Ventura, Camila De França, Araújo Vinícius, Giovanny Carter, Jillian Da, Esteves Guerra Gallo, Luciana Martinez-Cajas, Jorge Mckeown, Sandra Peixoto, Henry Pereira, Silva Schaub, Bruno Velez, Maria Ventura, Liana
Source	PMC
abstract	BACKGROUND: Although it is known that Zika virus (ZIKV) infection during pregnancy may lead to microcephaly in the fetus, the prognostic factors associated with this tragic disorder remain unclear. We conducted a systematic review and meta-analysis to assess the prognostic factors associated with the incidence of microcephaly in congenital ZIKV infection. METHODS: We conducted a comprehensive search in Ovid MEDLINE, Ovid MEDLINE (R) Epub ahead of print, Embase, Embase Classic, Web of Science, CINAHL, Cochrane CENTRAL, LILACS, and various thesis databases to identify human studies reporting microcephaly associated with congenital ZIKV infection. We requested primary data from the authors of the included studies to calculate summary estimates and conduct the meta-analysis of the most prevalent factors. RESULTS: We screened 4106 titles and abstracts, and identified 12 studies for inclusion in the systematic review. The assessment of ZIKV infection and the definition of microcephaly varied among studies. A total of 6154 newborns/fetuses were enrolled; of those, 1120 (18.20%) had a diagnostic of ZIKV infection, of which 509 (45.45%) were diagnosed with microcephaly. Nine studies addressed the link between congenital ZIKV infection and neurological findings in newborns/fetuses. Half of the studies provided primary data. Three out of 11 factors of interest seem to be prognostic factors of microcephaly: infant’s sex – males compared to females: Relative Risk (RR) 1.30, 95% Confidence Interval (95% CI) 1.14 to 1.49; the stage of pregnancy when infection occurred – infection in the first trimester of pregnancy compared to infection at other stages of pregnancy: RR 1.41, 95% CI 1.09 to 1.82; and asymptomatic infection compared to symptomatic infection during pregnancy: RR 0.68; 95% CI 0.60 to 0.77. CONCLUSION: Our findings support the female-biased resistance hypothesis and reinforce the risk associated with the stage of pregnancy when ZIKV infection occurs. Continued surveillance of ZIKV infection during pregnancy is needed to identify additional factors that could contribute to developing microcephaly in affected fetuses. PROTOCOL REGISTRATION: This systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO), registration no. CRD 42018088075.
has issue date	2020-06-01(xsd:dateTime)
bibo:doi	10.1186/s12889-020-08946-5
has license	cc-by
sha1sum (hex)	6d52f97cb057010306b87ff415a92d24bfeda388
schema:url	https://doi.org/10.1186/s12889-020-08946-5
resource representing a document's title	Another piece of the Zika puzzle: assessing the associated factors to microcephaly in a systematic review and meta-analysis
has PubMed Central identifier	PMC7266116
schema:publication	BMC Public Health
resource representing a document's body	covid:6d52f97cb057010306b87ff415a92d24bfeda388#body_text
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