About: Phylogenetic Analysis of Feline Coronavirus Strains in an Epizootic Outbreak of Feline Infectious Peritonitis

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About: Phylogenetic Analysis of Feline Coronavirus Strains in an Epizootic Outbreak of Feline Infectious Peritonitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Phylogenetic Analysis of Feline Coronavirus Strains in an Epizootic Outbreak of Feline Infectious Peritonitis
Creator	Gruffydd-Jones, T Siddell, S Barker, E Helps, C Tasker, S Day, M Porter, E Burton, K Fews, D Harley, R Tuplin, C
topic	covid:6d75608f235a3ce869c6806dd1761ee437190cac#this
Source	Medline; PMC
abstract	BACKGROUND: Feline coronavirus (FCoV) infection is common. In a small percentage of cats, FCoV infection is associated with the fatal disease feline infectious peritonitis (FIP). Genetically distinct virulent and avirulent strains of FCoV might coexist within a cat population. OBJECTIVES: To determine whether the strains of FCoV in FIP‐affected cats are closely related or genetically distinct from the fecally derived strains of FCoV in contemporary‐asymptomatic cats during an epizootic outbreak of FIP. ANIMALS: Four cats euthanized because of FIP and 16 asymptomatic cats. METHODS: This prospective outbreak investigation was initiated during an outbreak of FIP in cats within or rehomed from a rescue/rehoming center. Postmortem samples were collected from cats with FIP and contemporaneous fecal samples from asymptomatic cats. RNA was purified from tissue and fecal samples, FCoV gene fragments were reverse transcribed, PCR‐amplified using novel primers, and sequenced. Sequences were aligned with ClustalW and compared with published FCoV sequences. RESULTS: FCoV RNA was detected in all 4 FIP cat postmortem samples and in 9 of the 16 fecal samples from contemporary‐asymptomatic cats. Novel primers successfully amplified fragments from 4 regions of the genome for all FCoV‐positive samples. Phylogenetic analysis showed that the FIP‐associated strains of FCoV from the outbreak were very closely related to the fecally derived strains of FCoV from contemporary‐asymptomatic cats. CONCLUSIONS AND CLINICAL IMPORTANCE: Sequence analysis provided no evidence that genetically distinct virulent and avirulent strains of FCoV were present during this FIP outbreak.
has issue date	2013-03-20(xsd:dateTime)
bibo:doi	10.1111/jvim.12058
bibo:pmid	23517431
has license	no-cc
sha1sum (hex)	6d75608f235a3ce869c6806dd1761ee437190cac
schema:url	https://doi.org/10.1111/jvim.12058
resource representing a document's title	Phylogenetic Analysis of Feline Coronavirus Strains in an Epizootic Outbreak of Feline Infectious Peritonitis
has PubMed Central identifier	PMC7166722
has PubMed identifier	23517431
schema:publication	J Vet Intern Med
resource representing a document's body	covid:6d75608f235a3ce869c6806dd1761ee437190cac#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/6d75608f235a3ce869c6806dd1761ee437190cac
is schema:about of	named entity 'FIP' named entity 'virulent' named entity 'FCoV' named entity 'Feline coronavirus' named entity 'avirulent' named entity 'Phylogenetic Analysis' named entity 'Epizootic' named entity 'FCoV' named entity 'euthanasia' named entity 'postmortem' named entity 'FIP' named entity 'FCoV' named entity 'High-Fidelity' named entity 'asymptomatic' named entity 'subpopulation' named entity 'protein' named entity 'envelope protein' named entity 'avirulent' named entity 'antigen' named entity 'amplicon' named entity 'alternative hypothesis' named entity 'membrane glycoprotein' named entity 'gene' named entity 'RNA' named entity 'cDNA' named entity 'Ascitic fluid' named entity 'sequenced' named entity 'FIP' named entity 'intestines' named entity 'proximal' named entity 'PCR' named entity 'FIP' named entity 'sequence data' named entity 'genome' named entity 'Formalin' named entity 'membrane glycoprotein' named entity 'FCoV' named entity 'primers' named entity 'FCoV' named entity 'gastrointestinal disease' named entity 'FCoV' named entity 'avirulent' named entity 'mesentery' named entity 'coronavirus' named entity 'histopathology' named entity 'epizootic' named entity 'RT-qPCR' named entity 'ascitic fluid' named entity 'reverse transcribed' named entity 'membrane glycoprotein' named entity 'malaise' named entity 'FIP' named entity 'mutation' named entity 'amplicon' named entity 'genome' named entity 'conserved regions' named entity 'bootstrap values' named entity 'FIP' named entity 'phylogenetic' named entity 'FIP' named entity 'dNTP' named entity 'feces' named entity 'genome sequences' named entity 'feline infectious peritonitis' named entity 'sequence data' named entity 'FIP' named entity 'FCoV' named entity 'PCR' named entity 'carboxyl'

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