About: Toward a Durable Anti‐HIV Gene Therapy Based on RNA Interference

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Toward a Durable Anti‐HIV Gene Therapy Based on RNA Interference
Creator	Berkhout, Ben
Source	Medline; PMC
abstract	Basic research in the field of molecular biology led to the discovery of the mechanism of RNA interference (RNAi) in Caenorhabditis elegans in 1998. RNAi is now widely appreciated as an important gene control mechanism in mammals, and several RNAi‐based gene‐silencing applications have already been used in clinical trials. In this review I will discuss RNAi approaches to inhibit the pathogenic human immunodeficiency virus type 1 (HIV‐1), which establishes a chronic infection that would most likely require a durable gene therapy approach. Viruses, such as HIV‐1, are particularly difficult targets for RNAi attack because they mutate frequently, which allows viral escape by mutation of the RNAi target sequence. Combinatorial RNAi strategies are required to prevent viral escape.
has issue date	2009-09-24(xsd:dateTime)
bibo:doi	10.1111/j.1749-6632.2009.04972.x
bibo:pmid	19796072
has license	no-cc
sha1sum (hex)	6d774c6f685b01cb79ff9f61fb7a6e6a9fc8a461
schema:url	https://doi.org/10.1111/j.1749-6632.2009.04972.x
resource representing a document's title	Toward a Durable Anti‐HIV Gene Therapy Based on RNA Interference
has PubMed Central identifier	PMC7167650
has PubMed identifier	19796072
schema:publication	Ann N Y Acad Sci
resource representing a document's body	covid:6d774c6f685b01cb79ff9f61fb7a6e6a9fc8a461#body_text
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