About: Viral Etiology of Acute Exacerbations of COPD in Hong Kong

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Viral Etiology of Acute Exacerbations of COPD in Hong Kong
Creator	Hui, David Ip, Margaret To, Kin-Wang Chan, Michael Chan, Paul Ko, Fanny Ng, Susanna Tang, Julian Chau, Shirley
Source	Elsevier; Medline; PMC
abstract	Introduction Viral respiratory infections may precipitate acute exacerbations of COPD (AECOPD). However, little is known about viral etiology related to AECOPD in Asia. We aimed to study the viral etiology of AECOPD in Hong Kong. Methods Patients admitted to an acute hospital in Hong Kong with AECOPD were recruited prospectively from May 1, 2004, to April 30, 2005. Nasopharyngeal aspirate was collected and assessed by polymerase chain reaction (PCR) and viral culture. Spirometry was performed in the stable phase at 2 to 3 months after hospital discharge. Results There were 262 episodes of AECOPD among 196 patients (mean age, 75.7 ± 7.7 years [± SD]; 160 men). Mean FEV1 was 39.6 ± 18.9% of predicted normal, and FEV1/FVC ratio was 58.0 ± 15.2%. Fifty-eight episodes (22.1%) yielded positive viral PCR results. The viruses identified were influenza A (7.3%), coronavirus OC43 (4.6%), rhinovirus (3.1%), influenza B (2.7%), and respiratory syncytial virus (2.3%). The diagnostic yield of viral identification by PCR was 2.7 times higher than that based on conventional viral culture. The rates of identifying a positive viral etiology by PCR were similar among the subjects with FEV1 ≥ 50%, ≥ 30 to 50%, and < 30% of predicted normal. Viral infection appeared to have no effect on subsequent readmissions or mortality rate over a study period of 1 year Conclusion Influenza A and two less-attended viruses, coronavirus OC43 and rhinovirus, were the common etiologic agents in patients hospitalized with AECOPD in Hong Kong. These should be considered in developing diagnostic and intervening strategies pertaining to AECOPD.
has issue date	2007-09-30(xsd:dateTime)
bibo:doi	10.1378/chest.07-0530
bibo:pmid	17573516
has license	els-covid
sha1sum (hex)	6d9d10f3bc6cf0898e828758fe3c9e32797ba0b6
schema:url	https://doi.org/10.1378/chest.07-0530
resource representing a document's title	Viral Etiology of Acute Exacerbations of COPD in Hong Kong
has PubMed Central identifier	PMC7094736
has PubMed identifier	17573516
schema:publication	Chest
resource representing a document's body	covid:6d9d10f3bc6cf0898e828758fe3c9e32797ba0b6#body_text
is schema:about of	named entity 'COPD' named entity 'RESPIRATORY INFECTIONS' named entity 'POLYMERASE CHAIN REACTION' named entity 'ETIOLOGY' named entity 'INFLUENZA B' named entity 'VIRAL INFECTION' named entity 'CONCLUSION' named entity '160' named entity 'PATIENTS' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'ASSESSED' named entity 'DIAGNOSTIC' named entity 'HIGHER' named entity 'EPISODES' named entity 'ASIA' named entity 'STABLE' named entity 'DEVELOPING' named entity 'THESE' named entity 'BASED' named entity 'PERIOD' named entity 'CONVENTIONAL' named entity 'PRECIPITATE' named entity 'NO EFFECT' named entity 'HONG KONG' named entity 'IDENTIFYING' named entity 'YEAR' named entity 'RATIO' named entity 'VIRUSES' named entity '287' named entity 'VIRAL CULTURE' named entity '282' named entity 'AGE' named entity 'SPIROMETRY' named entity 'RELATED' named entity '50%' named entity 'FEV 1' named entity 'PCR' named entity '196' named entity 'LITTLE' named entity 'ACUTE EXACERBATIONS' named entity '3 MONTHS' named entity 'ABOUT' named entity 'VIRAL' named entity 'MEN' named entity 'APRIL' named entity 'RHINOVIRUS' named entity 'RATES' named entity 'PREDICTED' named entity '283' named entity 'SIMILAR' named entity 'RESULTS' named entity 'METHODS' named entity 'INTRODUCTION' named entity 'INFLUENZA A' named entity 'STRATEGIES' named entity 'COMMON' named entity '7.7' named entity 'ATTENDED' named entity 'IDENTIFIED' named entity 'PHASE' named entity 'ACUTE EXACERBATIONS' named entity 'ETIOLOGY' named entity 'STUDY' named entity '30%' named entity 'CONSIDERED' named entity 'HOSPITALIZED' named entity '2.7' named entity 'FIFTY-EIGHT' named entity 'NASOPHARYNGEAL ASPIRATE' named entity 'VIRAL IDENTIFICATION' named entity 'YEARS' named entity 'ACUTE HOSPITAL' named entity 'MEAN'

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