About: Autophagic machinery activated by dengue virus enhances virus replication

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Autophagic machinery activated by dengue virus enhances virus replication
Creator	Lee, Ying-Ray Liu, Hsiao-Sheng Wang, Jen-Ren Lei, Huan-Yao Liu, Ching-Chuan Lin, Yee-Shin Yeh, Trai-Ming Chen, Shun-Hua Jiang-Shieh, Ya-Fen Liu, Ming-Tao
Source	Elsevier; Medline; PMC
abstract	Abstract Autophagy is a cellular response against stresses which include the infection of viruses and bacteria. We unravel that Dengue virus-2 (DV2) can trigger autophagic process in various infected cell lines demonstrated by GFP-LC3 dot formation and increased LC3-II formation. Autophagosome formation was also observed under the transmission electron microscope. DV2-induced autophagy further enhances the titers of extracellular and intracellular viruses indicating that autophagy can promote viral replication in the infected cells. Moreover, our data show that ATG5 protein is required to execute DV2-induced autophagy. All together, we are the first to demonstrate that DV can activate autophagic machinery that is favorable for viral replication.
has issue date	2008-05-10(xsd:dateTime)
bibo:doi	10.1016/j.virol.2008.02.016
bibo:pmid	18353420
has license	els-covid
sha1sum (hex)	6d9da85d0033bda39063c0827b52037eeb5f25d1
schema:url	https://doi.org/10.1016/j.virol.2008.02.016
resource representing a document's title	Autophagic machinery activated by dengue virus enhances virus replication
has PubMed Central identifier	PMC7103294
has PubMed identifier	18353420
schema:publication	Virology
resource representing a document's body	covid:6d9da85d0033bda39063c0827b52037eeb5f25d1#body_text
is schema:about of	named entity 'VIRUS REPLICATION' named entity 'observed' named entity 'infection' named entity 'viruses' named entity 'Dengue virus' named entity 'cells' named entity 'demonstrated' named entity 'autophagic' named entity 'machinery' named entity 'MACHINERY' named entity 'AUTOPHAGY' named entity 'CELLS' named entity 'VIRUSES' named entity 'INDICATING' named entity 'PROTEIN ' named entity 'INDUCED' named entity 'GFP' named entity 'INTRACELLULAR' named entity 'DENGUE VIRUS' named entity 'VIRAL REPLICATION' named entity 'INCREASED' named entity 'DEMONSTRATED' named entity 'EXTRACELLULAR' named entity 'TRANSMISSION ELECTRON MICROSCOPE' named entity 'PROCESS' named entity 'DOT' named entity 'LC3' named entity 'REQUIRED' named entity 'FORMATION' named entity 'STRESSES' named entity 'ATG5 PROTEIN' named entity 'DENGUE VIRUS' named entity 'LC3-II' named entity 'ACTIVATE' named entity 'TRIGGER' named entity 'OUR' covid:arg/6d9da85d0033bda39063c0827b52037eeb5f25d1 named entity 'FAVORABLE' named entity 'EXECUTE' named entity 'INFECTED CELL' named entity 'PROMOTE' named entity 'IS A' named entity 'INFECTED' named entity 'INFECTION' named entity 'ACTIVATED' named entity 'CELL LINES' named entity 'MACHINERY' named entity 'AUTOPHAGOSOME FORMATION' named entity 'OBSERVED' named entity 'CELLULAR RESPONSE' named entity 'INCLUDE' named entity 'VARIOUS' named entity 'DATA' named entity 'BACTERIA.' named entity 'formation' named entity 'induced' named entity 'autophagy' named entity 'unravel' named entity 'autophagy' named entity 'cell lines' named entity 'autophagic' named entity 'GFP' named entity 'intracellular' named entity 'ATG5' named entity 'virus replication' named entity 'autophagosome' named entity 'autophagosome' named entity 'ATG5' named entity 'transmitted by mosquitoes' named entity 'GFP' named entity 'autophagy' named entity 'p70S6K'

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