About: Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and Lyssaviruses In Vitro

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About: Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and Lyssaviruses In Vitro Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and Lyssaviruses In Vitro
Creator	Kellam, P Ferrara, F Smith, S Temperton, N Fife, M Gibson, M Wash, R Wright, E
Source	Medline; PMC
abstract	Interferon-inducible transmembrane protein 3 (IFITM3) is an effector protein of the innate immune system. It confers potent, cell-intrinsic resistance to infection by diverse enveloped viruses both in vitro and in vivo, including influenza viruses, West Nile virus, and dengue virus. IFITM3 prevents cytosolic entry of these viruses by blocking complete virus envelope fusion with cell endosome membranes. Although the IFITM locus, which includes IFITM1, -2, -3, and -5, is present in mammalian species, this locus has not been unambiguously identified or functionally characterized in avian species. Here, we show that the IFITM locus exists in chickens and is syntenic with the IFITM locus in mammals. The chicken IFITM3 protein restricts cell infection by influenza A viruses and lyssaviruses to a similar level as its human orthologue. Furthermore, we show that chicken IFITM3 is functional in chicken cells and that knockdown of constitutive expression in chicken fibroblasts results in enhanced infection by influenza A virus. Chicken IFITM2 and -3 are constitutively expressed in all tissues examined, whereas IFITM1 is only expressed in the bursa of Fabricius, gastrointestinal tract, cecal tonsil, and trachea. Despite being highly divergent at the amino acid level, IFITM3 proteins of birds and mammals can restrict replication of viruses that are able to infect different host species, suggesting IFITM proteins may provide a crucial barrier for zoonotic infections.
has issue date	2013-12-01(xsd:dateTime)
bibo:doi	10.1128/jvi.01443-13
bibo:pmid	24067955
has license	cc-by
sha1sum (hex)	6da3f66c681b4b60ce1f6f246340517b79b67137
schema:url	https://doi.org/10.1128/jvi.01443-13
resource representing a document's title	Chicken Interferon-Inducible Transmembrane Protein 3 Restricts Influenza Viruses and Lyssaviruses In Vitro
has PubMed Central identifier	PMC3838109
has PubMed identifier	24067955
schema:publication	J Virol
resource representing a document's body	covid:6da3f66c681b4b60ce1f6f246340517b79b67137#body_text
is schema:about of	named entity 'replication' named entity 'gastrointestinal tract' named entity 'TRANSMEMBRANE PROTEIN 3' named entity 'EFFECTOR PROTEIN' named entity 'RESTRICTS' named entity 'PREVENTS' named entity 'INNATE IMMUNE SYSTEM' named entity 'IFITM2' named entity 'SPECIES' named entity 'TO INFECT' named entity 'HIGHLY' named entity 'BURSA OF FABRICIUS' named entity 'IN VITRO' named entity 'HERE' named entity '2C CELL' named entity 'MEMBRANES' named entity 'CELL' named entity 'BIRDS' named entity 'PROTEINS' named entity 'BARRIER' named entity 'AVIAN' named entity 'RESISTANCE TO INFECTION' named entity 'INCLUDING' named entity 'DIVERSE' named entity 'ENDOSOME' named entity 'THESE' named entity 'INTERFERON' named entity 'FUSION' named entity 'PRESENT' named entity 'MAMMALIAN' named entity 'TRANSMEMBRANE PROTEIN 3' named entity 'INFLUENZA VIRUSES' named entity 'VIRUS ENVELOPE' named entity 'MAMMALS' named entity 'SYNTENIC' named entity 'CHICKENS' named entity 'PROVIDE' named entity 'ZOONOTIC INFECTIONS' named entity 'CHARACTERIZED' named entity 'DENGUE VIRUS' named entity 'EXPRESSED' named entity 'WEST NILE VIRUS' named entity 'COMPLETE' named entity 'PROTEIN ' named entity 'LOCUS' named entity 'GASTROINTESTINAL TRACT' named entity 'IN VITRO' named entity 'BEING' named entity 'DIFFERENT' named entity 'BLOCKING' named entity 'ALL TISSUES' named entity 'INFLUENZA VIRUSES' named entity 'ENTRY' named entity 'REPLICATION' named entity 'CECAL TONSIL' named entity 'EXAMINED' named entity 'VIRUSES' named entity 'INTRINSIC' named entity 'HOST SPECIES' named entity 'INTERFERON' named entity 'IFITM3' named entity 'IDENTIFIED' named entity 'CYTOSOLIC' named entity 'AMINO ACID LEVEL' named entity 'IN VIVO' named entity 'TRACHEA' named entity 'CHICKEN' named entity 'INDUCIBLE' named entity 'IFITM1' named entity 'RESTRICT' named entity 'INDUCIBLE' covid:arg/6da3f66c681b4b60ce1f6f246340517b79b67137 named entity 'mammalian species' named entity 'chickens'

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