About: Severe Measles Infection: The Spectrum of Disease in 36 Critically Ill Adult Patients

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Severe Measles Infection: The Spectrum of Disease in 36 Critically Ill Adult Patients
Creator	Messika, Jonathan Roch, Antoine Chemouni, Frank Darmon, Michaël Gaudry, Stéphane Guisset, Olivier Guérin, Claude Klouche, Kada Machado, Sonia Mercier, Emmanuelle Mrozek, Natacha Pujol, Wilfried Rafat, Cédric Ricard, Jean-Damien Schmidt, Matthieu Sonneville, Romain Teboul, Jean-Louis Dreyfuss,
Source	PMC
abstract	France has recently witnessed a nationwide outbreak of measles. Data on severe forms of measles in adults are lacking. We sought to describe the epidemiologic, clinical, treatment, and prognostic aspects of the disease in adult patients who required admission to an intensive care unit (ICU). We performed a retrospective analysis of a cohort of 36 adults admitted to a total of 64 ICUs throughout France for complications of measles from January 1, 2009, to December 31, 2011. All cases of measles were confirmed by serologic testing and/or reverse transcription polymerase chain reaction. The cohort consisted of 21 male and 15 female patients, with a median age of 29.2 years (25th–75th interquartile range [IQR], 27.2–34.2 yr) and a median Simplified Acute Physiology Score (SAPS II) of 13 (IQR, 9–18). Among the 26 patients whose measles vaccination status was documented, none had received 2 injections. One patient had developed measles during childhood. Underlying comorbid conditions included chronic respiratory disease in 9 patients, immunosuppression in 7 patients, and obesity in 3 patients, while measles affected 5 pregnant women. Respiratory complications induced by measles infection led to ICU admission in 32 cases, and measles-related neurologic complications led to ICU admission in 2 cases. Two patients were admitted due to concurrent respiratory and neurologic complications. Bacterial superinfection of measles-related airway infection was suspected in 28 patients and was documented in 8. Four cases of community-acquired pneumonia, 6 cases of ventilator-associated pneumonia, 1 case of tracheobronchitis, and 2 cases of sinusitis were microbiologically substantiated. Of 11 patients who required mechanical ventilation, 9 developed acute respiratory distress syndrome (ARDS). Among the patients with ARDS, extraalveolar air leak complications occurred in 4 cases. Five patients died, all of whom were severely immunocompromised. On follow-up, 1 patient had severe chronic respiratory failure related to lung fibrosis, and 2 patients had mild lower limb paraparesis along with bladder dysfunction, both of which were ascribable to measles-induced encephalitis and myelitis. Among the 5 pregnant patients, the course of measles infection was uneventful, albeit 1 patient underwent emergent cesarean delivery because of fetal growth restriction. Measles is a disease with protean and potentially deceptive clinical manifestations, especially in the immunocompromised patient. Measles-associated pneumonitis and its complications, and less commonly postinfectious encephalomyelitis, are the main source of morbidity and mortality. In contrast with the usually benign course of the disease in immunocompetent patients, measles occurring in immunocompromised patients gives rise to lethal complications including ARDS, with or without bacterial superinfection. Other patients potentially at high risk for severe measles are young adults and pregnant women. Measles pneumonitis may predispose to air leak disease in patients using mechanical ventilation. To date, vaccination remains the most potent tool to control measles infection.
has issue date	2013-09-13(xsd:dateTime)
bibo:doi	10.1097/md.0b013e3182a713c2
bibo:pmid	23982057
has license	no-cc
sha1sum (hex)	6da81d5a45c958bbd505b7775741c9e7a94ca04b
schema:url	https://doi.org/10.1097/md.0b013e3182a713c2
resource representing a document's title	Severe Measles Infection: The Spectrum of Disease in 36 Critically Ill Adult Patients
has PubMed Central identifier	PMC4553975
has PubMed identifier	23982057
schema:publication	Medicine (Baltimore)
resource representing a document's body	covid:6da81d5a45c958bbd505b7775741c9e7a94ca04b#body_text
is schema:about of	named entity 'Patients' named entity 'Infection' named entity 'INFECTION' named entity 'RECENTLY' named entity 'ADULT' named entity 'OUTBREAK' named entity 'FRANCE' named entity 'WITNESSED' named entity 'SEVERE' named entity 'SPECTRUM' named entity 'CRITICALLY ILL' named entity 'PATIENTS' named entity 'MEASLES' named entity 'DISEASE' named entity 'nationwide' named entity 'immunosuppression' named entity 'S. pneumoniae' named entity 'rash' named entity 'NK cell' named entity 'magnetic resonance imaging' named entity 'motor aphasia' named entity 'chemotherapy' named entity 'immunization' named entity 'ICU' named entity 'cystic lesions' named entity 'pneumonia' named entity 'myelitis' named entity 'chest X-ray' named entity 'chemotherapy' named entity 'hemolysis' named entity 'rash' named entity 'France' named entity 'nationwide outbreak' named entity 'France' named entity 'Critically Ill' named entity 'measles' named entity 'cardiovascular' named entity 'serologic testing' named entity 'Enterobacter cloacae' named entity 'ICU' named entity 'acute liver failure' named entity 'PIE' named entity 'plasma exchange' named entity 'neurologic' named entity 'liver enzyme' named entity 'respiratory failure' named entity 'interstitial pneumonitis' named entity 'lobar consolidation' named entity 'H1N1 infection' named entity 'central nervous' named entity 'transplant glomerulopathy' named entity 'serologic' named entity 'measles' named entity 'rash' named entity 'rhabdomyolysis' named entity 'barotrauma' named entity 'MIBE' named entity 'body mass index' named entity 'general practitioner' named entity 'rhabdomyolysis' named entity 'measles' named entity 'symptom' named entity 'ICU' named entity 'adverse effects'

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