About: Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E

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About: Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E
Creator	Wang, Wei Wang, Ping Hu, Qinxue Xiao, Gengfu Zhang, Di Fu, Ming Guan, Xinmeng Hu, Kai Li, Mei Liu, Yalan Zhang, Mudan Zheng, Zifeng
Source	Elsevier; Medline; PMC
abstract	Abstract It has been well documented that BST2 restricts the release of enveloped viruses by cross-linking newly produced virions to the cell membrane. However, it is less clear whether and how BST2 inhibits the release of enveloped viruses which bud via the secretory pathway. Here, we demonstrated that BST2 restricts the release of Japanese encephalitis virus (JEV) whose budding occurs at the ER-Golgi intermediate compartment, and in turn, JEV infection downregulates BST2 expression. We further found that the JEV envelope protein E, but not other viral components, significantly downregulates BST2 with the viral protein M playing an auxiliary role in the process. Envelope protein E-mediated BST2 downregulation appears to undergo lysosomal degradation pathway. Additional study revealed that the transmembrane domain and the coiled-coil domain (CC) of BST2 are the target domains of viral protein E and that the N- and C-terminal membrane anchors and the CC domain of BST2 are essential for blocking JEV release. Our results together indicate that the release of enveloped viruses whose budding take place in an intracellular compartment can be restricted by BST2.
has issue date	2017-10-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2017.07.008
bibo:pmid	28710958
has license	els-covid
sha1sum (hex)	6df6c727033e287c0d7cd1bc277f071868608d71
schema:url	https://doi.org/10.1016/j.virol.2017.07.008
resource representing a document's title	Japanese encephalitis virus counteracts BST2 restriction via its envelope protein E
has PubMed Central identifier	PMC7111294
has PubMed identifier	28710958
schema:publication	Virology
resource representing a document's body	covid:6df6c727033e287c0d7cd1bc277f071868608d71#body_text
is schema:about of	named entity 'JEV' named entity 'release' named entity 'ENVELOPE PROTEIN E' named entity 'TARGET' named entity 'REVEALED' named entity 'CELL MEMBRANE' named entity 'INTRACELLULAR' named entity 'TAKE PLACE' named entity 'VIRUSES' named entity 'BUD' named entity 'DOMAIN' named entity 'CROSS-LINKING' named entity 'RESULTS' named entity 'TURN' named entity 'COILED-COIL DOMAIN' named entity 'MEDIATED' named entity 'BUDDING' named entity 'NEWLY' named entity 'CLEAR' named entity 'HERE' named entity 'BST2' named entity 'OUR' named entity 'ANCHORS' named entity 'HOW' named entity 'ITS' named entity 'BUT' named entity 'BLOCKING' named entity 'RESTRICTION' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'C-TERMINAL' named entity 'SECRETORY PATHWAY' named entity 'BST2' named entity 'LYSOSOMAL DEGRADATION PATHWAY' named entity 'STUDY' named entity 'ROLE' named entity 'VIRAL COMPONENTS' named entity 'PROTEIN E' named entity 'MEMBRANE' named entity 'VIRAL PROTEIN' named entity 'DOWNREGULATION' named entity 'RESTRICTED' named entity 'ADDITIONAL' named entity 'VIRIONS' named entity 'RELEASE' named entity 'ESSENTIAL' named entity 'PROCESS' named entity 'FOUND' named entity 'PROTEIN M' named entity 'DEMONSTRATED' named entity 'RESTRICTS' named entity 'TRANSMEMBRANE DOMAIN' named entity 'ER-GOLGI INTERMEDIATE COMPARTMENT' named entity 'INFECTION' named entity 'DOCUMENTED' named entity 'ENVELOPE PROTEIN E' named entity 'THE CELL' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'COMPARTMENT' named entity 'AUXILIARY' named entity 'PLAYING' named entity 'EXPRESSION' named entity 'target' named entity 'documented' named entity 'However' named entity 'transmembrane domain' named entity 'cell membrane' named entity 'Envelope' named entity 'release' named entity 'JEV' named entity 'JEV'

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