About: Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement

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About: Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement
Creator	Carubbi, Chiara Dallari, Dante Favero, Marta Goldring, Mary Goldring, Steven Grigolo, Brunella Olivotto, Eleonora Otero, Miguel Ramonda, Roberta Stilli, Stefano Tassinari, Enrico Traina, Francesco Trisolino, Giovanni
Source	PMC
abstract	BACKGROUND: Hip osteoarthritis (HOA) is the most common hip disorder and a major cause of disability in the adult population, with an estimated prevalence of end-stage disease and total hip replacement. Thus, the diagnosis, prevention, and treatment of the early stages of the disease in young adults are crucial to reduce the incidence of end-stage HOA. The purpose of this study was to determine whether (1) a relationship among the inflammatory status of labrum and synovium collected from patients with femoroacetabular impingement (FAI) would exist; and (2) to investigate the associations among the histopathological features of joint tissues, the pre-operative symptoms and the post-operative outcomes after arthroscopic surgery. METHODS: Joint tissues from 21 patients undergoing hip arthroscopy for FAI were collected and their histological and immunohistochemical features were correlated with clinical parameters. RESULTS: Synovial mononuclear cell infiltration was observed in 25% of FAI patients, inversely correlated with the hip disability and osteoarthritis outcome score (HOOS) pain and function subscales and with the absolute and relative change in total HOOS. All the labral samples showed some pattern of degeneration and 67% of the samples showed calcium deposits. The total labral score was associated with increased CD68 positive cells in the synovium. The presence of labral calcifications, along with the chondral damage worsened the HOOS post-op symptoms (adjusted R-square = 0.76 p = 0.0001). CONCLUSIONS: Our study reveals a relationship between the histologic labral features, the synovial inflammation, and the cartilage condition at the time of FAI. The presence of labral calcifications, along with the cartilage damage and the synovitis negatively affects the post-operative outcomes in patients with FAI.
has issue date	2020-02-28(xsd:dateTime)
bibo:doi	10.1186/s13018-020-01610-z
bibo:pmid	32111250
has license	cc-by
sha1sum (hex)	6e01b775f979f6c0b56e6d2facdb1f8d98d059fc
schema:url	https://doi.org/10.1186/s13018-020-01610-z
resource representing a document's title	Labral calcification plays a key role in hip pain and symptoms in femoroacetabular impingement
has PubMed Central identifier	PMC7049200
has PubMed identifier	32111250
schema:publication	J Orthop Surg Res
resource representing a document's body	covid:6e01b775f979f6c0b56e6d2facdb1f8d98d059fc#body_text
is schema:about of	named entity 'function' named entity 'CD68' named entity 'disease' named entity 'The presence' named entity 'FAI' named entity 'CD68' named entity 'CALCIUM DEPOSITS' named entity 'SCORE' named entity 'SYNOVITIS' covid:arg/6e01b775f979f6c0b56e6d2facdb1f8d98d059fc named entity 'features' named entity 'histopathological' named entity 'Synovial' named entity 'condition' named entity 'pattern' named entity 'prevention' named entity 'correlated' named entity 'positive' named entity 'Methods' named entity 'R-square' named entity 'total hip replacement' named entity 'synovium' named entity 'perivascular' named entity 'acetabular' named entity 'debridement' named entity 'knee meniscus' named entity 'Cartilage' named entity 'fibrosis' named entity 'immunohistochemical' named entity 'histological' named entity 'hip joint' named entity 'synovial membrane' named entity 'cartilage' named entity 'cartilage damage' named entity 'daily living activities' named entity 'Calcium' named entity 'ordinal data' named entity 'H&E' named entity 'cartilage' named entity 'Histological' named entity 'labrum' named entity 'CD68' named entity 'total hip replacement' named entity 'mononuclear cell infiltration' named entity 'inflammatory' named entity 'labral tear' named entity '0.49' named entity 'post-operative' named entity 'joint space' named entity 'clinical outcomes' named entity 'end-stage' named entity 'statistical analysis' named entity 'histological analysis' named entity 'chondral' named entity '0.01' named entity 'SPSS' named entity 'hip pain' named entity 'acetabular' named entity 'immunohistochemical' named entity 'disability' named entity 'histological analysis' named entity 'monocytes' named entity 'young adults' named entity 'Synovial' named entity 'cartilage' named entity 'correlation' named entity 'Synovial membrane' named entity 'BMI' named entity 'menisci'

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