About: Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong

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About: Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong
Creator	Lee, N Cockram, C Sung, J Chan, P Lui, G Tsoi, K Yu, I
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: The clinico-epidemiological significance of human metapneumovirus (hMPV) detected during the SARS outbreak is unknown. OBJECTIVES: To characterize a nosocomial hMPV outbreak during the 2003 SARS epidemic. STUDY DESIGN AND METHODS: All available nasopharyngeal aspirate (NPA) collected from confirmed patients during the first 8 weeks of the SARS outbreak in 2003 were tested for hMPV by a nested RT-PCR assay targeting the F-gene. Clinico-epidemiological information was used to analyze the relationship of hMPV co-infection to specific risk factors (demographics/symptoms/outcomes; status as health-care workers (HCWs)/patients; history of exposure/contact; ward location). Multivariate logistic regression analysis was performed to determine independent risk factors. RESULTS: An hMPV outbreak occurred during 6–16 March 2003 (first week of the Hong Kong SARS epidemic). hMPV RNA was detected in 31 of 155 (20%) NPAs from SARS patients. HCW status (OR 2.72, 95% CI 1.11–6.68; p = 0.029) or epidemiological linkage to the SARS outbreak ward (OR 3.59, 95% CI 1.42–9.05; p = 0.007) were independent factors associated with hMPV infection. Symptoms of cough and coryza were more common in co-infected individuals (22.6% vs. 15.9%) but this was not statistically significant. Other clinical manifestations and outcomes were not different in co-infected patients. CONCLUSIONS: A major nosocomial hMPV outbreak involving HCWs occurred during the early SARS epidemic. Patients with dual hMPV and SARS infection were not sicker than those with SARS infection only.
has issue date	2007-11-01(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2007.08.015
bibo:pmid	17936066
has license	no-cc
sha1sum (hex)	6e77b13ede56cbfa1b31ab21486ea5bcff926869
schema:url	https://doi.org/10.1016/j.jcv.2007.08.015
resource representing a document's title	Co-circulation of human metapneumovirus and SARS-associated coronavirus during a major nosocomial SARS outbreak in Hong Kong
has PubMed Central identifier	PMC7108220
has PubMed identifier	17936066
schema:publication	J Clin Virol
resource representing a document's body	covid:6e77b13ede56cbfa1b31ab21486ea5bcff926869#body_text
is schema:about of	named entity 'HONG KONG' named entity 'NPAs' named entity 'NPA' named entity 'logistic regression' named entity 'early' named entity 'independent' named entity 'All' named entity 'human metapneumovirus' named entity 'WORKERS' named entity 'OUTCOMES' named entity '2.72' named entity 'COMMON' named entity 'LOGISTIC REGRESSION ANALYSIS' named entity 'LOCATION' named entity 'HEALTH' named entity 'INDEPENDENT' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'INDIVIDUALS' named entity 'A MAJOR' named entity 'EPIDEMIOLOGICAL' named entity 'CO-INFECTION' named entity 'GENE' named entity 'USED' named entity 'INFECTION ONLY' named entity '8 WEEKS' named entity 'MARCH' named entity 'SARS' named entity 'UNKNOWN' named entity 'TO CHARACTERIZE' covid:arg/6e77b13ede56cbfa1b31ab21486ea5bcff926869 named entity 'A MAJOR' named entity 'CARE' named entity 'STATISTICALLY SIGNIFICANT' named entity 'RELATIONSHIP' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'CIRCULATION' named entity 'CLINICAL MANIFESTATIONS' named entity 'PATIENTS' named entity 'OBJECTIVES' named entity 'EXPOSURE' named entity 'ASSOCIATED WITH' named entity 'RISK FACTORS' named entity 'INFECTION' named entity 'COLLECTED' named entity 'WARD' named entity 'HISTORY OF' named entity 'RESULTS' named entity 'STATUS' named entity 'SARS' named entity 'STUDY DESIGN' named entity 'INFECTED' named entity 'WEEK' named entity 'OCCURRED' named entity 'CONFIRMED' named entity 'RT-PCR ASSAY' named entity 'DETERMINE' named entity 'BUT' named entity 'COUGH' named entity 'DETECTED' named entity 'NESTED' named entity 'OUTBREAK' named entity 'AVAILABLE' named entity 'EARLY' named entity 'PERFORMED' named entity 'SYMPTOMS' named entity 'TESTED FOR' named entity 'DIFFERENT' named entity 'RNA' named entity 'EPIDEMIC' named entity 'NASOPHARYNGEAL ASPIRATE' named entity 'TARGETING' named entity 'INVOLVING' named entity 'CORYZA' named entity 'CONCLUSIONS' named entity 'MULTIVARIATE LOGISTIC REGRESSION'

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