About: Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine

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About: Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine
Creator	He, Yongqun Xiang, Zuoshuang Osorio, Jorge Adams, L Bounpheng, Mangkey Brake, David Brown, William Burrage, Thomas Clavijo, Alfonso Laughlin, Richard Lopera-Madrid, Jaime Mwangi, Waithaka Neilan, John Subramanya, Sandesh
Source	Elsevier; Medline; PMC
abstract	Abstract A reverse vaccinology system, Vaxign, was used to identify and select a subset of five African Swine Fever (ASF) antigens that were successfully purified from human embryonic kidney 293 (HEK) cells and produced in Modified vaccinia virus Ankara (MVA) viral vectors. Three HEK-purified antigens [B646L (p72), E183L (p54), and O61R (p12)], and three MVA-vectored antigens [B646L, EP153R, and EP402R (CD2v)] were evaluated using a prime-boost immunization regimen swine safety and immunogenicity study. Antibody responses were detected in pigs following prime-boost immunization four weeks apart with the HEK-293-purified p72, p54, and p12 antigens. Notably, sera from the vaccinees were positive by immunofluorescence on ASFV (Georgia 2007/1)-infected primary macrophages. Although MVA-vectored p72, CD2v, and EP153R failed to induce antibody responses, interferon-gamma (IFN-γ+) spot forming cell responses against all three antigens were detected one week post-boost. The highest IFN-γ+ spot forming cell responses were detected against p72 in pigs primed with MVA-p72 and boosted with the recombinant p72. Antigen-specific (p12, p72, CD2v, and EP153R) T-cell proliferative responses were also detected post-boost. Collectively, these results are the first demonstration that ASFV subunit antigens purified from mammalian cells or expressed in MVA vectors are safe and can induce ASFV-specific antibody and T-cell responses following a prime-boost immunization regimen in swine.
has issue date	2017-03-31(xsd:dateTime)
bibo:doi	10.1016/j.vetimm.2017.01.004
bibo:pmid	28241999
has license	els-covid
sha1sum (hex)	6e88df413a56de4ad8f6d04f66667e7ffe0c2af2
schema:url	https://doi.org/10.1016/j.vetimm.2017.01.004
resource representing a document's title	Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine
has PubMed Central identifier	PMC7112906
has PubMed identifier	28241999
schema:publication	Veterinary Immunology and Immunopathology
resource representing a document's body	covid:6e88df413a56de4ad8f6d04f66667e7ffe0c2af2#body_text
is schema:about of	named entity 'AFRICAN SWINE FEVER' named entity 'immunization' named entity 'evaluated' named entity 'African Swine Fever' named entity 'purified' named entity 'boosted' named entity 'responses' named entity 'antigens' named entity 'subunit' named entity 'ANKARA' named entity 'USED' named entity 'ASFV' named entity 'SERA' named entity 'RESPONSES' named entity 'POST' named entity 'T-CELL' named entity 'INDUCE' named entity '90%' named entity 'SPECIFIC ANTIBODY' named entity 'RECOMBINANT' named entity 'REGIMEN' named entity 'SPOT' named entity 'SAFETY' named entity 'POSITIVE' named entity 'PRIMED' named entity 'IMMUNIZATION' named entity 'VECTORED' named entity 'IMMUNOGENICITY' named entity 'SAFETY' named entity 'ANTIBODY' named entity 'SUBSET' named entity 'ONE WEEK' named entity 'S T' named entity 'FORMING' named entity 'MAMMALIAN CELL' named entity 'MODIFIED' named entity 'SWINE' named entity 'DERIVED' named entity 'ANTIGENS' named entity 'VECTORED' named entity 'SUBUNIT' named entity 'SWINE' named entity 'IMMUNOGENICITY STUDY' named entity 'EMBRYONIC KIDNEY' named entity 'DETECTED' named entity 'FOLLOWING' named entity 'AFRICAN SWINE FEVER' named entity 'MACROPHAGES' named entity 'FAILED' named entity '293' named entity 'EVALUATED' named entity 'SYSTEM' named entity 'ANTIGENS' named entity 'T A' named entity 'TO IDENTIFY' named entity 'PRIMARY' named entity 'P72' named entity 'CELLS' named entity 'HIGHEST' named entity 'PIGS' named entity 'VACCINIA' named entity 'BOOST' named entity 'THESE' named entity 'P12' named entity 'PROLIFERATIVE' named entity 'RESULTS' named entity 'MODIFIED' named entity 'MAMMALIAN'

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