About: Kidney manifestations of mild, moderate and severe coronavirus disease 2019: a retrospective cohort study

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Kidney manifestations of mild, moderate and severe coronavirus disease 2019: a retrospective cohort study
Creator	Wang, Li Tang, Yun Zheng, Ling Lei, Yu Zhao, Jia He, Yanan Hong, Daqing Li, Guisen Long, Lin Song, Xiaofei Wang, Amanda Wen, Ergang
Source	Medline; PMC
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 3 million patients globally. Previous data from Wuhan city showed that acute kidney injury (AKI), proteinuria and hematuria occurred frequently in patients with severe COVID-19. However, the prevalence of kidney injury in milder cases remains unclear. METHODS: This retrospective study included two major consecutive cohorts of COVID-19 patients in Sichuan Province. Baseline characteristics, laboratory data including renal function, proteinuria and dipstick hematuria, and other laboratory parameters were collected. A subgroup of patients was followed up for 2–4 weeks to evaluate the short-term outcome of renal impairment. RESULTS: Overall, 168 COVID-19-positive patients were included in the study. The majority of patients (79.7%) were diagnosed with mild or moderate disease. Half of patients presented with fever; however, in The Tibetan cohort, fever only occurred in 13.4% of patients. On hospital admission, proteinuria and dipstick hematuria were noted in 18.4% and 17.4% of patients, respectively, while AKI only occurred in one patient. Further analysis showed that severe or critical COVID-19 was associated with higher risk of proteinuria [relative risk (RR) 7.37, 95% confidence interval (CI) 2.45–22.18, P = 3.8 × 10(−4)] and dipstick hematuria (RR 8.30, 95% CI 2.69–25.56, P = 2.3 × 10(−4)). Proteinuria, dipstick hematuria, or the combination of proteinuria and hematuria could significantly predict severe or critical severe COVID-19. CONCLUSIONS: Proteinuria and dipstick hematuria are not uncommon in patients with COVID-19 infection, especially in severe or critical cases.
has issue date	2020-05-09(xsd:dateTime)
bibo:doi	10.1093/ckj/sfaa083
bibo:pmid	32695324
has license	cc-by-nc
sha1sum (hex)	6ece110a9a242bc4fdfef9fd39f0400ed3146643
schema:url	https://doi.org/10.1093/ckj/sfaa083
resource representing a document's title	Kidney manifestations of mild, moderate and severe coronavirus disease 2019: a retrospective cohort study
has PubMed Central identifier	PMC7239220
has PubMed identifier	32695324
schema:publication	Clin Kidney J
resource representing a document's body	covid:6ece110a9a242bc4fdfef9fd39f0400ed3146643#body_text
is schema:about of	named entity 'COVID-19' named entity 'However' named entity 'frequently' named entity 'COVID' named entity 'acute kidney injury' named entity 'kidney injury' named entity 'coronavirus disease 2019' named entity 'retrospective cohort study' named entity 'viral load' named entity 'renal function' named entity 'blood circulation' named entity 'SARS-CoV-2 virus' named entity 'virus' named entity 'hypertension' named entity 'COVID-19' named entity 'proteinuria' named entity 'CVVH' named entity 'pneumonia' named entity 'AKI' named entity 'follow-up' named entity 'proteinuria' named entity 'multiple organ dysfunction syndrome' named entity 'interquartile range' named entity 'radiographic' named entity 'Hubei Province' named entity 'Chengdu' named entity 'COVID' named entity 'hypertension' named entity 'reverse transcription-polymerase chain reaction' named entity 'risk factor' named entity 'sample size' named entity 'fever' named entity 'normal range' named entity 'COVID-19' named entity 'normal temperature' named entity 'plasma' named entity 'BNP' named entity 'ACE2 receptor' named entity 'pneumonia' named entity 'urea' named entity 'hematuria' named entity 'fever' named entity 'hematuria' named entity 'normal temperature' named entity 'erythrocyte sedimentation rate' named entity 'COVID-19' named entity 'COVID-19 disease' named entity 'AKI' named entity 'follow-up' named entity 'COVID-19' named entity 'exact mechanism' named entity 'renal tubules' named entity 'BNP' named entity 'SARS' named entity 'Wuhan' named entity 'viral RNA' named entity 'COVID-19' named entity 'Tibetans' named entity 'hematuria' named entity 'albuminuria' named entity 'Chinese National Health Commission' named entity 'lactate dehydrogenase' named entity 'normal range' named entity 'hematuria' named entity 'angiotensin-converting enzyme' named entity 'cTnT' named entity 'proteinuria' named entity 'COVID-19' named entity 'Chengdu' named entity 'COVID'

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