About: Synthesis of Organotin Polyamine Ethers Containing Acyclovir and their Preliminary Anticancer and Antiviral Activity

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About: Synthesis of Organotin Polyamine Ethers Containing Acyclovir and their Preliminary Anticancer and Antiviral Activity Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Synthesis of Organotin Polyamine Ethers Containing Acyclovir and their Preliminary Anticancer and Antiviral Activity
Creator	Bassett, Kelly Bleicher, Robert Carraher, Charles Roehr, Joanne Roner, Michael Sabir, Theodore Shahi, Kimberely
Source	PMC
abstract	Organotin polyamine ethers containing acyclovir in their backbone were synthesized in moderate to high yield employing the aqueous interfacial polycondensation system. The products are high molecular weight polymers. Infrared spectroscopy of the products shows new bands characteristic of the formation of Sn–N and Sn–O bonds consistent with the proposed structure. MALDI-TOF MS below 2000 Da shows the presence of organotin and acyclovir units containing these two moieties. The products show moderate inhibition of a number of cancer cell lines and exhibit the ability to inhibit a number of viruses, particularly the herpes simplex virus-1 and varicella zoster virus that are responsible for herpes, chicken pox and shingles.
has issue date	2006-10-26(xsd:dateTime)
bibo:doi	10.1007/s10904-006-9050-y
bibo:pmid	32214932
has license	no-cc
sha1sum (hex)	6ee04672b96acaa4cd7bd174e44160de387c55a1
schema:url	https://doi.org/10.1007/s10904-006-9050-y
resource representing a document's title	Synthesis of Organotin Polyamine Ethers Containing Acyclovir and their Preliminary Anticancer and Antiviral Activity
has PubMed Central identifier	PMC7088028
has PubMed identifier	32214932
schema:publication	J Inorg Organomet Polym Mater
resource representing a document's body	covid:6ee04672b96acaa4cd7bd174e44160de387c55a1#body_text
is schema:about of	named entity 'cancer cell' named entity 'SHINGLES' named entity 'INHIBITION' named entity 'THEIR' named entity 'SYSTEM' covid:arg/6ee04672b96acaa4cd7bd174e44160de387c55a1 named entity 'inhibition' named entity 'ethers' named entity 'moderate' named entity 'formation' named entity 'high yield' named entity 'herpes simplex virus' named entity 'number' named entity 'ethers' named entity 'acyclovir' named entity 'viruses' named entity 'cancer cell lines' named entity 'Acyclovir' named entity 'Anticancer' named entity 'Polyamine' named entity 'polymers' named entity 'viruses' named entity 'antiviral agents' named entity 'potassium bromide' named entity 'sindbis virus' named entity 'ion' named entity 'antiviral activity' named entity 'cancer cell lines' named entity 'Standard deviation' named entity 'RNA' named entity 'virus' named entity 'Turel' named entity 'monomeric' named entity 'reaction mixture' named entity 'moiety' named entity 'acyclovir' named entity 'VIII' named entity 'Vaccinia' named entity 'antiviral activity' named entity 'pyridyl' named entity 'antibacterial' named entity 'viruses' named entity 'lattice' named entity 'co-monomer' named entity 'polymers' named entity 'thymidine kinase' named entity 'RNA viruses' named entity 'Infrared' named entity 'reovirus' named entity 'polymer' named entity 'polymers' named entity 'polymers' named entity 'acyclovir' named entity 'aromatic' named entity 'acyclovir' named entity 'functional groups' named entity 'mmol' named entity 'polymers' named entity 'acyclovir' named entity 'polymer' named entity 'viruses' named entity 'MALDI' named entity 'moiety' named entity 'polymers' named entity 'acyclovir' named entity 'ion' named entity 'FBS' named entity 'alkyl' named entity 'Reaction conditions' named entity 'acyclovir' named entity 'polymers' named entity 'VZV' named entity 'antivirals' named entity 'polymers' named entity 'organotin'

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