About: Combined throat/nasal swab sampling for SARS-CoV-2 is equivalent to nasopharyngeal sampling

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About: Combined throat/nasal swab sampling for SARS-CoV-2 is equivalent to nasopharyngeal sampling Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Combined throat/nasal swab sampling for SARS-CoV-2 is equivalent to nasopharyngeal sampling
Creator	Achterberg, & Thijsen, S Vlek, A Wesselius, T
Source	Medline; PMC
abstract	PURPOSE: PCR on a nasopharyngeal sample is the reference method for the detection of SARS-nCoV-2. However, combined throat/nasal sampling as a testing method has several advantages. We compared the combined throat/nasal sampling with nasopharyngeal sampling for detection of SARS-CoV-2 in healthcare workers suspected of COVID-19. METHODS: In 107 healthcare workers with symptoms of COVID-19, combined throat/nasal sampling and nasopharyngeal sampling was performed. Detection of SARS-CoV-2 was performed by RT-PCR targeting. RESULTS: A total of 80 healthcare workers (74.8%) tested negative with both sampling methods, and 25 healthcare workers (23.4%) tested positive with both sampling methods. There were two discrepant results with positive PCR in combined throat/nasal swabs and negative PCR in nasopharyngeal swabs (1.9%). The κ index for concordance between the 2 sampling methods was high (0.95). The median cycle threshold (Ct) value of PCR on nasopharyngeal samples was significantly lower than the Ct value of PCR on combined throat/nasal samples (19 (IQR 17–20) versus 21 (IQR 18–29) cycles, p value 0.01). CONCLUSION: Combined throat/nasal swabs yield a similar sensitivity to detect SARS-CoV-2 as nasopharyngeal swabs and are a good alternative sampling method, despite a lower Ct value for the nasopharyngeal samples.
has issue date	2020-07-14(xsd:dateTime)
bibo:doi	10.1007/s10096-020-03972-y
bibo:pmid	32666481
has license	no-cc
sha1sum (hex)	6ee8da8f0a54164cb9cc471fc3010f7c93066cd1
schema:url	https://doi.org/10.1007/s10096-020-03972-y
resource representing a document's title	Combined throat/nasal swab sampling for SARS-CoV-2 is equivalent to nasopharyngeal sampling
has PubMed Central identifier	PMC7359435
has PubMed identifier	32666481
schema:publication	Eur J Clin Microbiol Infect Dis
resource representing a document's body	covid:6ee8da8f0a54164cb9cc471fc3010f7c93066cd1#body_text
is schema:about of	named entity 'sampling' named entity 'detection' named entity 'SARS-CoV-2' named entity 'sampling' named entity 'healthcare' named entity 'SARS-CoV-2' named entity 'detection' named entity 'SARS-CoV-2' named entity 'negative' named entity 'nasal' named entity 'swabs' named entity 'nasal' named entity 'swabs' named entity 'combined' named entity 'sensitivity' named entity 'sampling' named entity 'detect' named entity 'Combined' named entity 'nCoV' named entity 'sampling method' named entity 'nasopharyngeal' named entity 'SARS-CoV-2' named entity 'healthcare workers' named entity 'SARS' named entity 'sampling methods' named entity 'PCR' named entity 'sampling' named entity 'sampling methods' named entity 'sampling methods' named entity 'Chicago' named entity 'SARS-CoV-2' named entity 'virological' named entity 'fever' named entity 'COVID-19' named entity 'nasopharyngeal swabs' named entity 'symptom' named entity 'healthcare workers' named entity 'oropharyngeal' named entity 'nasopharyngeal swab' named entity 'interquartile range' named entity 'oropharyngeal' named entity 'nasopharyngeal swabs' named entity 'WHO' named entity 'Foster City' named entity 'nylon' named entity 'nasopharyngeal swabs' named entity 'SARS-CoV-2' named entity 'sampling methods' named entity 'healthcare workers' named entity 'saliva' named entity 'PCR' named entity 'sampling methods' named entity 'Roche' named entity 'oropharyngeal' named entity 'PCR' named entity 'sampling techniques' named entity 'Healthcare workers' named entity 'SARS-CoV-2' named entity 'Italy' named entity 'Windows' named entity 'sampling method' named entity 'tested positive' named entity 'loss of smell' named entity 'dyspnoea' named entity 'PCR' named entity 'sore throat' named entity 'SPSS' named entity 'nasopharyngeal swab' named entity 'Copan' named entity 'general hospital' named entity 'sampling methods' named entity 'PCR' named entity 'RNA' named entity 'RT-PCR' named entity 'healthcare workers' named entity 'Netherlands' named entity 'nylon' named entity 'SARS-CoV-2'

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