About: Outbreak of pandemic 2009 influenza A/H1N1 infection in the hematology ward: fatal clinical outcome of hematopoietic stem cell transplant recipients and emergence of the H275Y neuraminidase mutation

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About: Outbreak of pandemic 2009 influenza A/H1N1 infection in the hematology ward: fatal clinical outcome of hematopoietic stem cell transplant recipients and emergence of the H275Y neuraminidase mutation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Outbreak of pandemic 2009 influenza A/H1N1 infection in the hematology ward: fatal clinical outcome of hematopoietic stem cell transplant recipients and emergence of the H275Y neuraminidase mutation
Creator	Iioka, Futoshi Nakamura, Fumihiko Ohno, Hitoshi Ryuichi, • Yoshitomo, Sada
topic	covid:6f294afbc59a8f1dc94fd7b52e54527e3022c59c#this
Source	PMC
abstract	We report an outbreak of pandemic 2009 influenza A/H1N1 virus (2009 H1N1) infection that occurred in the hematology ward of our institution during the 2010–2011 influenza season. A total of seven hospitalized patients with hematologic tumors, including five recipients of hematopoietic stem cell transplantation (HSCT), successively developed rapid influenza detection test (RIDT)-positive influenza A; four patients had laboratory-confirmed 2009 H1N1 infection. Three HSCT recipients required mechanical ventilation support and two were admitted to the intensive care unit; they died of progressive respiratory failure despite receiving available anti-viral drugs. We implemented outbreak-control measures including transferal of RIDT-positive patients to a single-patient room and chemoprophylaxis with oseltamivir. We note that the H275Y neuraminidase mutation was detected in respiratory specimens from three patients, who were administered therapeutic or prophylactic dosages of oseltamivir. The present report demonstrates that the nosocomial 2009 H1N1 outbreak in the hematology ward led to fatal clinical outcomes and the emergence of a resistant virus at a markedly high rate.
has issue date	2012-07-08(xsd:dateTime)
bibo:doi	10.1007/s12185-012-1139-1
bibo:pmid	22773299
has license	no-cc
sha1sum (hex)	6f294afbc59a8f1dc94fd7b52e54527e3022c59c
schema:url	https://doi.org/10.1007/s12185-012-1139-1
resource representing a document's title	Outbreak of pandemic 2009 influenza A/H1N1 infection in the hematology ward: fatal clinical outcome of hematopoietic stem cell transplant recipients and emergence of the H275Y neuraminidase mutation
has PubMed Central identifier	PMC7101624
has PubMed identifier	22773299
schema:publication	Int J Hematol
resource representing a document's body	covid:6f294afbc59a8f1dc94fd7b52e54527e3022c59c#body_text
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is schema:about of	named entity 'virus' named entity 'emergence' named entity 'infection' named entity 'infection' named entity 'PROGRESSIVE RESPIRATORY FAILURE' covid:arg/6f294afbc59a8f1dc94fd7b52e54527e3022c59c named entity 'pandemic' named entity 'respiratory failure' named entity 'high' named entity 'patients' named entity 'patients' named entity 'oseltamivir' named entity 'rapid' named entity 'specimens' named entity '2009' named entity 'developed' named entity 'dosages' named entity 'oseltamivir' named entity 'total' named entity 'hematology' named entity 'ward' named entity 'virus' named entity 'hematology' named entity 'influenza' named entity 'infection' named entity 'infection' named entity 'nosocomial' named entity 'hematologic' named entity 'tumors' named entity 'hematopoietic stem cell transplant' named entity 'infection' named entity 'influenza' named entity 'tumor cells' named entity 'HSCT' named entity 'hematology' named entity 'influenza A virus' named entity 'mechanical ventilation' named entity 'clinical outcomes' named entity 'virus' named entity 'H1N1 virus' named entity 'influenza vaccine' named entity 'pro-inflammatory cytokines' named entity 'fatality rate' named entity 'respiratory failure' named entity 'chemoprophylaxis' named entity 'influenza' named entity 'intensive care unit' named entity 'multiple myeloma' named entity 'virus' named entity 'H1N1 virus' named entity 'influenza' named entity 'chemokines' named entity 'oseltamivir' named entity 'H1N1 infection' named entity 'H1N1 infection' named entity 'white cell' named entity 'angioimmunoblastic T cell lymphoma' named entity 'oseltamivir' named entity 'mortality rates' named entity 'risk factors' named entity 'respiratory distress' named entity 'HSCT' named entity 'tumors' named entity 'CD20' named entity 'immunocompromised patients' named entity '2009 H1N1' named entity 'HSCT' named entity 'virus' named entity 'hematology' named entity 'zanamivir' named entity 'oseltamivir' named entity 'infection control' named entity 'influenza' named entity 'co-infection' named entity 'oseltamivir'

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