About: Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines

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About: Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
Creator	De Clercq, Erik Naesens, Lieve Vázquez, Santiago López-Querol, Marta Camps, Pelayo Mallol, Jordi Montaner, Silvia Profire, Lenuta Duque, María Kelly, John Sureda, Francesc Radhika Prathalingam, S
source	Elsevier; Medline; PMC
abstract	The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.
has issue date	2009-04-01(xsd:dateTime)
bibo:doi	10.1016/j.bmc.2009.02.007
bibo:pmid	19251424
has license	green-oa
sha1sum (hex)	6f3c265edcc79d8926bde1a4ae95c6106206c154
schema:url	https://doi.org/10.1016/j.bmc.2009.02.007
resource representing a document's title	Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines
has PubMed Central identifier	PMC3217223
has PubMed identifier	19251424
schema:publication	Bioorganic & Medicinal Chemistry
resource representing a document's body	covid:6f3c265edcc79d8926bde1a4ae95c6106206c154#body_text
is schema:about of	named entity '282' named entity 'amantadine' named entity 'antagonists' named entity 'DISPLAYED' named entity 'SIGNIFICANT' named entity 'SYNTHESIS' named entity '282' named entity 'EVALUATION' named entity 'PHARMACOLOGICAL' named entity 'SYNTHESIS' named entity 'TESTED' named entity 'AMANTADINE' named entity 'ANTIVIRAL ACTIVITY' named entity 'BUT' named entity 'EVALUATED' named entity 'ACTIVE' named entity 'TRYPANOCIDAL ACTIVITY' named entity 'MEMANTINE' named entity 'NMDA RECEPTOR ANTAGONISTS' named entity 'LEVEL' named entity 'REPORTED' covid:arg/6f3c265edcc79d8926bde1a4ae95c6106206c154 named entity 'NMDA receptor' named entity 'None' named entity 'pharmacological' named entity '37 °C' named entity 'T. brucei' named entity 'EtOH' named entity 'NMDA receptor antagonism' named entity 'EtOH' named entity 'HCl' named entity 'UV light' named entity 'influenza A virus' named entity 'parent compound' named entity 'MeOH' named entity 'NMDA receptor antagonist' named entity 'species complex' named entity '7.92' named entity 'formaldehyde' named entity 'benzyl group' named entity 'Column chromatography' named entity 'CH 2' named entity 'substituent' named entity 'GraphPad Prism' named entity 'HMBC' named entity 'chromatography' named entity 'HCl' named entity 'RNA viruses' named entity '2-propanol' named entity 'gas chromatograph' named entity 'EtOAc' named entity 'amine' named entity 'amine' named entity 'NMDA' named entity 'Amine' named entity 'amantadine' named entity 'parasites' named entity 'potency' named entity 'HCl' named entity 'hemocytometer' named entity '75.4' named entity 'CH 2' named entity 'vacuo' named entity 'antiviral activity' named entity 'HCl' named entity 'mmol' named entity 'amines' named entity 'silica gel' named entity 'mmol' named entity 'Phenyl'

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