About: Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury
Creator	Aguilar-Cevallos, Jorge Garcia, Elisa Ibarra, Antonio Silva-Garcia, Raul
Source	PMC
abstract	Spinal cord injury results in a life-disrupting series of deleterious interconnected mechanisms encompassed by the primary and secondary injury. These events are mediated by the upregulation of genes with roles in inflammation, transcription, and signaling proteins. In particular, cytokines and growth factors are signaling proteins that have important roles in the pathophysiology of SCI. The balance between the proinflammatory and anti-inflammatory effects of these molecules plays a critical role in the progression and outcome of the lesion. The excessive inflammatory Th1 and Th17 phenotypes observed after SCI tilt the scale towards a proinflammatory environment, which exacerbates the deleterious mechanisms present after the injury. These mechanisms include the disruption of the spinal cord blood barrier, edema and ion imbalance, in particular intracellular calcium and sodium concentrations, glutamate excitotoxicity, free radicals, and the inflammatory response contributing to the neurodegenerative process which is characterized by demyelination and apoptosis of neuronal tissue.
has issue date	2016-06-23(xsd:dateTime)
bibo:doi	10.1155/2016/9476020
bibo:pmid	27418745
has license	cc-by
sha1sum (hex)	6ff089187feaca34bce964cc052bd1fa0f016d40
schema:url	https://doi.org/10.1155/2016/9476020
resource representing a document's title	Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury
has PubMed Central identifier	PMC4935915
has PubMed identifier	27418745
schema:publication	Mediators Inflamm
resource representing a document's body	covid:6ff089187feaca34bce964cc052bd1fa0f016d40#body_text
is schema:about of	named entity 'MEDIATED' named entity 'GENES' named entity 'INCLUDE' named entity 'HAVE' named entity 'GLUTAMATE EXCITOTOXICITY' named entity 'BALANCE' named entity 'SPINAL CORD' named entity 'UPREGULATION' named entity 'RESULTS' named entity 'IMBALANCE' named entity 'DISRUPTING' named entity 'TISSUE' named entity 'CRITICAL' named entity 'INFLAMMATION' named entity 'IMPORTANT' named entity 'ACTIVATION' named entity 'IN VITRO' named entity 'OBSERVED' named entity 'PARTICULAR' named entity 'CONCENTRATIONS' named entity 'ANTI-INFLAMMATORY' named entity 'NEURODEGENERATIVE PROCESS' named entity 'TH17' named entity 'PROGRESSION' named entity 'GROWTH FACTORS' named entity 'EFFECTS' named entity 'PRESENT' named entity 'SECONDARY' named entity 'SODIUM' named entity 'SIGNALING' named entity 'PROTEINS' named entity 'TRANSCRIPTION' named entity 'NEURONAL' named entity 'INFLAMMATORY' named entity 'SCALE' named entity 'INFLAMMATORY RESPONSE' named entity 'DEMYELINATION' named entity 'ROLES' named entity 'PLAYS' named entity 'CYTOKINES' named entity 'DISRUPTION' named entity 'ION' named entity 'EDEMA' named entity 'SPINAL CORD INJURY' named entity 'IN VIVO' named entity 'EXCESSIVE' named entity 'SERIES' named entity 'CONTRIBUTING' named entity 'INTRACELLULAR CALCIUM' named entity 'SCI' named entity 'LESION' named entity 'SPINAL CORD INJURY' named entity 'INJURY' named entity 'TILT' named entity 'FREE RADICALS' named entity 'APOPTOSIS' named entity 'CHARACTERIZED' named entity 'MOLECULES' named entity 'CYTOKINE ' named entity 'GROWTH FACTOR' named entity 'EVENTS' named entity 'PHENOTYPES' named entity 'LIFE' named entity 'PATHOPHYSIOLOGY' named entity 'MECHANISMS' named entity 'ROLE' named entity 'OUTCOME' named entity 'TH1' named entity 'THESE' named entity 'EXACERBATES' named entity 'CORD BLOOD' named entity 'ENVIRONMENT' named entity 'PRIMARY' named entity 'BARRIER' named entity 'glutamate' named entity 'signaling proteins' named entity 'Spinal cord injury' named entity 'neurodegenerative process'

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