About: Targeting malaria parasite invasion of red blood cells as an antimalarial strategy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
Creator	Beeson, James De Koning-Ward, Tania Balbin, Juan Boyle, Michelle Burns, Amy Dans, Madeline Gilson, Paul Wilson, Danny
Source	Medline; PMC
abstract	Plasmodium spp. parasites that cause malaria disease remain a significant global-health burden. With the spread of parasites resistant to artemisinin combination therapies in Southeast Asia, there is a growing need to develop new antimalarials with novel targets. Invasion of the red blood cell by Plasmodium merozoites is essential for parasite survival and proliferation, thus representing an attractive target for therapeutic development. Red blood cell invasion requires a co-ordinated series of protein/protein interactions, protease cleavage events, intracellular signals, organelle release and engagement of an actin-myosin motor, which provide many potential targets for drug development. As these steps occur in the bloodstream, they are directly susceptible and exposed to drugs. A number of invasion inhibitors against a diverse range of parasite proteins involved in these different processes of invasion have been identified, with several showing potential to be optimised for improved drug-like properties. In this review, we discuss red blood cell invasion as a drug target and highlight a number of approaches for developing antimalarials with invasion inhibitory activity to use in future combination therapies.
has issue date	2019-02-11(xsd:dateTime)
bibo:doi	10.1093/femsre/fuz005
bibo:pmid	30753425
has license	cc-by-nc
sha1sum (hex)	6ff291580760e93781c11fad9b343080261f7982
schema:url	https://doi.org/10.1093/femsre/fuz005
resource representing a document's title	Targeting malaria parasite invasion of red blood cells as an antimalarial strategy
has PubMed Central identifier	PMC6524681
has PubMed identifier	30753425
schema:publication	FEMS Microbiol Rev
resource representing a document's body	covid:6ff291580760e93781c11fad9b343080261f7982#body_text
is schema:about of	named entity 'development' named entity 'develop' named entity 'invasion' named entity 'targets' named entity 'red blood cell' named entity 'merozoites' named entity 'susceptible' named entity 'drug development' named entity 'parasite' named entity 'red blood cells' named entity 'OCCUR' named entity 'PROLIFERATION' named entity 'release' named entity 'survival' named entity 'potential' named entity 'parasite' named entity 'provide' named entity 'parasites' named entity 'interactions' named entity 'artemisinin combination therapies' named entity 'drug target' named entity 'Targeting' named entity 'merozoites' named entity 'Plasmodium' named entity 'parasite' named entity 'antimalarials' named entity 'actin-myosin' named entity 'protease' named entity 'protein' named entity 'drug target' named entity 'bloodstream' named entity 'malaria' named entity 'processes' named entity 'range' named entity 'chemokine receptors' named entity 'antiretroviral' named entity 'Calcium signalling' named entity 'ATP' named entity 'Plasmepsin' named entity 'drug development' named entity 'RBC' named entity 'scleroglucan' named entity 'vectors' named entity 'blood stage' named entity 'Phase 1a' named entity 'CCR5' named entity 'tight junction' named entity 'C-terminal' named entity 'binding affinity' named entity 'drug resistance' named entity 'organelle' named entity 'antimalarials' named entity 'malaria' named entity 'rhoptry' named entity 'merozoite' named entity 'glycan' named entity 'binding pocket' named entity 'merozoite' named entity 'malaria parasites' named entity 'blood stage' named entity 'RBC' named entity 'Host cell' named entity 'myosin' named entity 'schizont' named entity 'antiretroviral drug' named entity 'molecule' named entity 'rodent' named entity 'human malaria' named entity 'phosphorylation' named entity 'gametocytes' named entity 'azithromycin' named entity 'merozoites' named entity 'Screening compounds' named entity 'tight junction'

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