About: Virus and cystic fibrosis: Rhinoviruses are associated with exacerbations in adult patients()

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Virus and cystic fibrosis: Rhinoviruses are associated with exacerbations in adult patients()
Creator	Goffard, Anne Dewilde, Anny Engelmann, Ilka Pin, Isabelle Delhaes, Laurence Herwegh, Stéphanie Lambert, Valérie Perrez, Thierry Pinel, Claudine Prévotat, Anne Salleron, Julia
Source	Elsevier; Medline; PMC
abstract	BACKGROUND: Few studies have suggested the potential role of respiratory viruses in cystic fibrosis (CF) exacerbation, but their real impact is probably underestimated. METHOD: Sixty-four sputum samples collected from 46 adult patients were included in the study: 33 samples were collected during exacerbation of CF, and 31 during the stable phase. After extraction, nucleic acids were tested for the presence of respiratory viruses. When rhinovirus (HRV) was detected, the 5′UTR and VP4/2 regions were sequenced, and phylogenetically analyzed. The characteristics of patients in exacerbation and stable phase were compared. RESULTS: Viruses were found in 25% of samples. The HRV viruses were the most frequently detected followed by coronaviruses. Only the HRV detection was significantly associated with the occurrence of CF pulmonary exacerbation (p < 0.027). Characterization of 5′UTR and VP4/2 regions of the HRV genome specified that HRV-A, -B, -C were detected. All HRV-C were recombinant HRV-Ca. CONCLUSIONS: HRV were the most frequently detected viruses; their detection was significantly associated with the occurrence of an exacerbation. The reality of viral recombination between HRV was demonstrated in CF patients for the first time, raising the role of viruses in lung microbiota. Further studies are now warranted to decipher virus impact in CF.
has issue date	2014-02-25(xsd:dateTime)
bibo:doi	10.1016/j.jcv.2014.02.005
bibo:pmid	24637203
has license	no-cc
sha1sum (hex)	7012c59d51676d44d172b0db08f55f10ec0452cd
schema:url	https://doi.org/10.1016/j.jcv.2014.02.005
resource representing a document's title	Virus and cystic fibrosis: Rhinoviruses are associated with exacerbations in adult patients()
has PubMed Central identifier	PMC7108260
has PubMed identifier	24637203
schema:publication	J Clin Virol
resource representing a document's body	covid:7012c59d51676d44d172b0db08f55f10ec0452cd#body_text
is schema:about of	named entity 'VIRUS' named entity 'All' named entity 'sequenced' named entity 'viruses' named entity 'impact' named entity 'pulmonary' named entity 'Virus' named entity 'CHARACTERIZATION' named entity 'UTR' named entity 'ROLE' named entity 'EXTRACTION' named entity 'LUNG' named entity 'STUDIES' named entity 'DETECTED' named entity 'PHASE' named entity 'FREQUENTLY' named entity 'RHINOVIRUS' named entity '28P' named entity 'GENOME' named entity 'PROBABLY' named entity 'HRV-A' named entity 'BACKGROUND' named entity 'ASSOCIATED WITH' named entity 'REGIONS' covid:arg/7012c59d51676d44d172b0db08f55f10ec0452cd named entity 'RHINOVIRUSES' named entity 'METHOD' named entity 'CYSTIC FIBROSIS' named entity 'REALITY' named entity 'ADULT' named entity 'ADULT' named entity 'PATIENTS' named entity 'CYSTIC FIBROSIS' named entity 'ASSOCIATED WITH' named entity 'HRV' named entity 'TIME' named entity 'HAVE' named entity 'STUDY' named entity 'SPECIFIED' named entity 'ANALYZED' named entity 'RECOMBINATION' named entity 'DECIPHER' named entity 'PRESENCE OF' named entity 'SAMPLES' named entity 'RECOMBINANT' named entity 'CHARACTERISTICS' named entity 'DETECTION' named entity 'FOUND' named entity 'RESPIRATORY VIRUSES' named entity 'VP4' named entity 'COMPARED' named entity 'SIXTY' named entity 'FOLLOWED BY' named entity 'IMPACT' named entity 'EXACERBATION' named entity 'OCCURRENCE' named entity 'REAL' named entity 'DEMONSTRATED' named entity 'VIRUSES' named entity 'BUT' named entity 'MICROBIOTA' named entity 'STABLE' named entity 'RESULTS' named entity 'INCLUDED' named entity 'THEIR' named entity 'CORONAVIRUSES' named entity 'VIRUS' named entity 'CONCLUSIONS' named entity 'NUCLEIC ACIDS' named entity 'POTENTIAL' named entity 'PATIENTS'

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