About: Mechanisms of transmissible gastroenteritis coronavirus neutralization

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About: Mechanisms of transmissible gastroenteritis coronavirus neutralization Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanisms of transmissible gastroenteritis coronavirus neutralization
Creator	Correa, Isabel Smerdou, Cristian Gebauer, Fatima Bullido, Mariaj Enjuanes', Luis Suns, Carlos
Source	Elsevier; Medline; PMC
abstract	Abstract Transmissible gastroenteritis virus (TGEV) was neutralized more than 109-fold with antibodies of a single specificity [monoclonal antibodies (MAbs)]. Most of the virus was neutralized in the first 2–3 min of a reversible reaction, which was followed by a second phase with a decreased neutralization rate and, in some cases, by a persistent fraction, which was a function of the MAb and of the antibody-to-virus ratio. Neutralization of TGEV is a specific event that requires the location of the epitope involved in the neutralization in the appropriate structural context, which is present in the wild-type virus but not in certain MAb escaping mutants. In neutralization of TGEV by binary combinations of MAbs specific for the same or for different antigenic sites, either no cooperation or a synergistic effect, respectively, was observed. Mechanisms of TGEV neutralization by MAbs were characterized at high, intermediate, and low antibody-to-virus ratios. Under these conditions, mainly three steps of the replication cycle were inhibited: binding of virus to the cell, internalization, and a step that takes place after internalization. In addition, virus aggregation could be responsible for the neutralization of 10 to 20% of virus infectivity.
has issue date	1990-08-31(xsd:dateTime)
bibo:doi	10.1016/0042-6822(90)90521-r
bibo:pmid	2164725
has license	els-covid
sha1sum (hex)	7018a22df61dff269b8f16195ef95b118158463d
schema:url	https://doi.org/10.1016/0042-6822%2890%2990521-r
resource representing a document's title	Mechanisms of transmissible gastroenteritis coronavirus neutralization
has PubMed Central identifier	PMC7131644
has PubMed identifier	2164725
schema:publication	Virology
resource representing a document's body	covid:7018a22df61dff269b8f16195ef95b118158463d#body_text
is schema:about of	named entity 'TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS' named entity 'MAb' named entity 'involved' named entity 'monoclonal antibodies' named entity 'step' named entity 'event' named entity 'neutralization' named entity 'BUT' named entity 'THESE' named entity 'WAS A' named entity 'COMBINATIONS' named entity 'STEP' named entity 'REPLICATION CYCLE' named entity 'COOPERATION' named entity 'MECHANISMS' named entity 'INTERMEDIATE' named entity 'EITHER' named entity 'VIRUS' named entity 'CONTEXT' named entity 'RATIOS' named entity 'ANTIBODY' named entity 'RATIO' named entity 'SITES' named entity 'SECOND PHASE' named entity 'OBSERVED' named entity 'LOW' named entity 'DECREASED' named entity 'NEUTRALIZATION' named entity 'SINGLE' named entity 'CASES' named entity 'PRESENT' named entity 'ANTIBODIES' named entity 'APPROPRIATE' named entity 'INTERNALIZATION' named entity '20%' named entity 'EVENT' named entity 'RATE' named entity 'FUNCTION' named entity 'WILD-TYPE' named entity 'MAB' named entity 'FOLD' named entity 'SYNERGISTIC' named entity 'ADDITION' named entity 'THE CELL' named entity 'HIGH' named entity 'MECHANISMS' named entity 'INHIBITED' named entity 'REVERSIBLE' named entity 'PERSISTENT' named entity 'MOST OF' named entity 'PLACE' named entity 'RESPONSIBLE' named entity 'SPECIFIC' named entity 'FOLLOWED BY' named entity 'IS A' named entity 'AGGREGATION' named entity 'BINDING' named entity 'STRUCTURAL' named entity 'CHARACTERIZED' named entity 'EPITOPE' named entity 'CONDITIONS' named entity 'TYPE VIRUS' named entity 'SPECIFICITY' named entity 'VIRUS INFECTIVITY' named entity 'BINARY' named entity 'FRACTION' named entity 'MORE THAN' named entity 'LOCATION' named entity 'MIN' named entity 'MUTANTS' named entity 'DIFFERENT' named entity 'COULD BE' named entity '10A' named entity '2-3' named entity 'INVOLVED' named entity 'REACTION'

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