About: Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV

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About: Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV
Creator	Letko, Michael Munster, Vincent Munster, Drs
source	BioRxiv; MedRxiv; Medline
abstract	Over the past 20 years, several coronaviruses have crossed the species barrier into humans, causing outbreaks of severe, and often fatal, respiratory illness. Since SARS- CoV was first identified in animal markets, global viromics projects have discovered thousands of coronavirus sequences in diverse animals and geographic regions. Unfortunately, there are few tools available to functionally test these novel viruses for their ability to infect humans, which has severely hampered efforts to predict the next zoonotic viral outbreak. Here we developed an approach to rapidly screen lineage B betacoronaviruses, such as SARS-CoV and the recent 2019-nCoV, for receptor usage and their ability to infect cell types from different species. We show that host protease processing during viral entry is a significant barrier for several lineage B viruses and that bypassing this barrier allows several lineage B viruses to enter human cells through an unknown receptor. We also demonstrate how different lineage B viruses can recombine to gain entry into human cells and confirm that human ACE2 is the receptor for the recently emerging 2019-nCoV.
has issue date	2020-01-22(xsd:dateTime)
bibo:doi	10.1101/2020.01.22.915660
bibo:pmid	32511294
has license	biorxiv
sha1sum (hex)	7034a6c6a996992c8811065bdd0a2326c2399da2
schema:url	https://doi.org/10.1101/2020.01.22.915660
resource representing a document's title	Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV
has PubMed identifier	32511294
schema:publication	bioRxiv
resource representing a document's body	covid:7034a6c6a996992c8811065bdd0a2326c2399da2#body_text
is schema:about of	named entity 'discovered' named entity 'BARRIER' named entity 'SARS-COV' named entity 'ANIMAL' named entity 'MARKETS' named entity 'projects' named entity 'Functional' named entity 'crossed the species barrier' named entity 'respiratory illness' named entity 'coronaviruses' named entity '2019-nCoV' named entity 'protease' named entity 'clade' named entity 'trypsin' named entity 'RBDs' named entity 'cell entry' named entity 'phenotypes' named entity 'dipeptidyl peptidase 4' named entity 'pseudotyping' named entity '293T' named entity 'receptor binding domain' named entity 'clade' named entity 'transfection' named entity 'coronavirus' named entity 'cross-species transmission' named entity 'HKU5' named entity 'cell entry' named entity 'clade' named entity 'CoV' named entity 'clade' named entity 'viruses' named entity 'membrane fusion' named entity 'species barrier' named entity 'cell entry' named entity 'RBDs' named entity 'Coronavirus' named entity 'ACE2' named entity 'protease' named entity 'vector' named entity 'pseudotype' named entity 'clade' named entity 'host-cell' named entity 'virus' named entity 'ACE2' named entity 'transfected' named entity 'exogenous' named entity '2019-nCoV' named entity 'clade' named entity 'deletions' named entity 'RBD' named entity 'viral entry' named entity 'protease' named entity 'protease' named entity 'viruses' named entity 'RBDs' named entity 'Protease' named entity 'trypsin' named entity 'ACE2' named entity 'interact' named entity 'amino acids' named entity 'virus' named entity 'viruses' named entity 'clade' named entity 'RBD' named entity 'recombinant' named entity 'clade' named entity 'clade' named entity 'SARS-CoV' named entity 'clade' named entity 'plasmid DNA' named entity 'clades' named entity 'L-glutamine' named entity 'clades' named entity 'reverse genetics' named entity 'clade' named entity 'virus' named entity 'protease' named entity 'clades' named entity 'clades' named entity 'phenotype'

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