About: Feline Foamy Virus Infection: Characterization of Experimental Infection and Prevalence of Natural Infection in Domestic Cats with and without Chronic Kidney Disease

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About: Feline Foamy Virus Infection: Characterization of Experimental Infection and Prevalence of Natural Infection in Domestic Cats with and without Chronic Kidney Disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Feline Foamy Virus Infection: Characterization of Experimental Infection and Prevalence of Natural Infection in Domestic Cats with and without Chronic Kidney Disease
Creator	Zheng, Xin Troyer, Ryan Beatty, Julia Bordicchia, Matteo Cianciolo, Rachel Dannemiller, Nicholas Gagne, Roderick Ledesma-Feliciano, Carmen Löchelt, Martin Miller, Craig Quimby, Jessica Vandewoude, Sue
source	Medline; PMC
abstract	Foamy viruses (FVs) are globally prevalent retroviruses that establish apparently apathogenic lifelong infections. Feline FV (FFV) has been isolated from domestic cats with concurrent diseases, including urinary syndromes. We experimentally infected five cats with FFV to study viral kinetics and tropism, peripheral blood mononuclear cell (PBMC) phenotype, urinary parameters, and histopathology. A persistent infection of primarily lymphoid tropism was detected with no evidence of immunological or hematologic perturbations. One cat with a significant negative correlation between lymphocytes and PBMC proviral load displayed an expanded FFV tissue tropism. Significantly increased blood urea nitrogen and ultrastructural kidney changes were noted in all experimentally infected cats, though chemistry parameters were not outside of normal ranges. Histopathological changes were observed in the brain, large intestine, and other tissues. In order to determine if there is an association of FFV with Chronic Kidney Disease, we additionally screened 125 Australian pet cats with and without CKD for FFV infection and found that FFV is highly prevalent in older cats, particularly in males with CKD, though this difference was not statistically significant compared to controls. Acute FFV infection was clinically silent, and while some measures indicated mild changes, there was no overt association of FFV infection with renal disease.
has issue date	2019-07-19(xsd:dateTime)
bibo:doi	10.3390/v11070662
bibo:pmid	31330990
has license	cc-by
sha1sum (hex)	708330752dfbcdd2731c67c7ed3263d1a911241e
schema:url	https://doi.org/10.3390/v11070662
resource representing a document's title	Feline Foamy Virus Infection: Characterization of Experimental Infection and Prevalence of Natural Infection in Domestic Cats with and without Chronic Kidney Disease
has PubMed Central identifier	PMC6669521
has PubMed identifier	31330990
schema:publication	Viruses
resource representing a document's body	covid:708330752dfbcdd2731c67c7ed3263d1a911241e#body_text
is schema:about of	named entity 'kinetics' named entity 'retroviruses' named entity 'urinary' named entity 'CKD' named entity 'compared' named entity 'infection' named entity 'CKD' named entity 'FFV' named entity 'Prevalence' named entity 'Feline' named entity 'Chronic Kidney Disease' named entity 'APPARENTLY' named entity 'HIGHLY' named entity 'GLOBALLY' named entity 'FOAMY' named entity 'CHRONIC KIDNEY DISEASE' named entity 'TISSUES' named entity 'ISOLATED' named entity 'PERSISTENT INFECTION' named entity 'DOMESTIC' named entity 'VIRUS INFECTION' named entity 'FELINE FOAMY VIRUS' named entity 'CHARACTERIZATION' named entity 'VIRUSES' named entity 'CORRELATION' named entity 'TROPISM' named entity 'NORMAL RANGES' named entity 'INFECTED' named entity 'PARAMETERS' named entity 'STATISTICALLY SIGNIFICANT' named entity 'URINARY' named entity 'HISTOPATHOLOGY' named entity 'AUSTRALIAN' named entity 'NATURAL INFECTION' named entity 'NEGATIVE' named entity 'ACUTE' named entity 'MEASURES' named entity 'STUDY' named entity 'NO EVIDENCE OF' named entity 'SYNDROMES' named entity 'INCLUDING' named entity 'EXPANDED ' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELL' named entity 'CATS' named entity 'CHRONIC KIDNEY DISEASE' named entity 'EXPERIMENTAL INFECTION' named entity 'COMPARED' named entity 'SILENT' named entity 'SIGNIFICANT' named entity 'KINETICS' named entity 'THE BRAIN' named entity 'HEMATOLOGIC' named entity 'FOUND' named entity 'LYMPHOID' named entity 'CHEMISTRY' named entity 'INDICATED' named entity 'LARGE INTESTINE' named entity 'CAT' named entity 'ASSOCIATION' named entity 'PBMC' named entity 'OUTSIDE' named entity 'CHANGES' named entity 'INFECTIONS' named entity 'KIDNEY' named entity 'LIFELONG' named entity 'LOAD' named entity '125' named entity 'CATS' named entity 'VIRAL' named entity 'MILD'

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