About: Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses

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About: Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses
Creator	Bartenschlager, Ralf Romero-Brey, Inés Chatel-Chaix, Laurent Bender, Silke Cortese, Mirko Fischer, Bernd Fischl, Wolfgang Ruggieri, Alessia Scaturro, Pietro Schieber, Nicole Schwab, Yannick Neufeldt, Christopher
Source	Elsevier; Medline; PMC
abstract	With no antiviral drugs or widely available vaccines, Dengue virus (DENV) constitutes a public health concern. DENV replicates at ER-derived cytoplasmic structures that include substructures called convoluted membranes (CMs); however, the purpose of these membrane alterations remains unclear. We determine that DENV nonstructural protein (NS)4B, a promising drug target with unknown function, associates with mitochondrial proteins and alters mitochondria morphology to promote infection. During infection, NS4B induces elongation of mitochondria, which physically contact CMs. This restructuring compromises the integrity of mitochondria-associated membranes, sites of ER-mitochondria interface critical for innate immune signaling. The spatio-temporal parameters of CM biogenesis and mitochondria elongation are linked to loss of activation of the fission factor Dynamin-Related Protein-1. Mitochondria elongation promotes DENV replication and alleviates RIG-I-dependent activation of interferon responses. As Zika virus infection induces similar mitochondria elongation, this perturbation may protect DENV and related viruses from innate immunity and create a favorable replicative environment.
has issue date	2016-09-14(xsd:dateTime)
bibo:doi	10.1016/j.chom.2016.07.008
bibo:pmid	27545046
has license	no-cc
sha1sum (hex)	70b1acb0757c8b0c6f193a7d2f17519bb73a7cef
schema:url	https://doi.org/10.1016/j.chom.2016.07.008
resource representing a document's title	Dengue Virus Perturbs Mitochondrial Morphodynamics to Dampen Innate Immune Responses
has PubMed Central identifier	PMC7105029
has PubMed identifier	27545046
schema:publication	Cell Host Microbe
resource representing a document's body	covid:70b1acb0757c8b0c6f193a7d2f17519bb73a7cef#body_text
is schema:about of	named entity 'Dengue Virus' named entity 'Dengue Virus' named entity '10 nm' named entity 'polyethylenimine' named entity 'ISG56' named entity 'NS4B' named entity 'protease' named entity 'NS4B' named entity 'penicillin' named entity 'voltage' named entity 'magnifying glass' named entity 'EGTA' named entity 'virus' named entity 'zeocin' named entity 'formaldehyde' named entity 'Huh7' named entity 'Mitochondrial proteins' named entity 'mitochondria' named entity 'immunofluorescence' named entity 'ERK1/2' named entity 'NS4B' named entity 'NS4B' named entity '4.7' named entity 'PBS' named entity 'acetone' named entity 'plasmids' named entity 'primary antibodies' named entity 'Electroporation' named entity 'HEPES' named entity 'Plano' named entity 'transduced' named entity 'Huh7' named entity 'virus' named entity 'Sigma-Aldrich' named entity 'plasmids' named entity 'lentiviruses' named entity 'immunoprecipitation' named entity 'gelatin' named entity 'PCR' named entity 'RNA replication' named entity 'recombination' named entity 'OPA1' named entity 'carbon' named entity 'Cas9' named entity 'Huh7' named entity 'Huh7' named entity 'α and β' named entity 'NS4B' named entity 'Sigma-Aldrich' named entity 'virus' named entity 'MFN1' named entity 'pTM' named entity 'Cell Signaling' named entity 'DENV' named entity 'Bioconductor' named entity 'virus' named entity 'gelatin' named entity 'flash-frozen' named entity 'Huh7' named entity 'PCR' named entity 'virus' named entity 'ATP5B' named entity 'cDNAs' named entity 'PBS' named entity 'mitochondria' named entity 'co-purified' named entity 'Sigma-Aldrich' named entity 'Auriga' named entity 'virus' named entity 'ATP5B'

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