About: Regulation of Coronaviral Poly(A) Tail Length during Infection

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About: Regulation of Coronaviral Poly(A) Tail Length during Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Regulation of Coronaviral Poly(A) Tail Length during Infection
Creator	Wu, Hung-Yi Jan, Eric Ke, Ting-Yung Liao, Wei-Yu Chang, Nai-Yun
topic	covid:710dd69c07a692bbdcd7261bb4508cd9935556c6#this
Source	Medline; PMC
abstract	The positive-strand coronavirus genome of ~30 kilobase in length and subgenomic (sg) mRNAs of shorter lengths, are 5’ and 3’-co-terminal by virtue of a common 5’-capped leader and a common 3’-polyadenylated untranslated region. Here, by ligating head-to-tail viral RNAs from bovine coronavirus-infected cells and sequencing across the ligated junctions, it was learned that at the time of peak viral RNA synthesis [6 hours postinfection (hpi)] the 3’ poly(A) tail on genomic and sgmRNAs is ~65 nucleotides (nt) in length. Surprisingly, this length was found to vary throughout infection from ~45 nt immediately after virus entry (at 0 to 4 hpi) to ~65 nt later on (at 6 h to 9 hpi) and from ~65 nt (at 6 h to 9 hpi) to ~30 nt (at 120-144 hpi). With the same method, poly(U) sequences of the same lengths were simultaneously found on the ligated viral negative-strand RNAs. Functional analyses of poly(A) tail length on specific viral RNA species, furthermore, revealed that translation, in vivo, of RNAs with the longer poly(A) tail was enhanced over those with the shorter poly(A). Although the mechanisms by which the tail lengths vary is unknown, experimental results together suggest that the length of the poly(A) and poly(U) tails is regulated. One potential function of regulated poly(A) tail length might be that for the coronavirus genome a longer poly(A) favors translation. The regulation of coronavirus translation by poly(A) tail length resembles that during embryonal development suggesting there may be mechanistic parallels.
has issue date	2013-07-29(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0070548
bibo:pmid	23923003
has license	cc-by
sha1sum (hex)	710dd69c07a692bbdcd7261bb4508cd9935556c6
schema:url	https://doi.org/10.1371/journal.pone.0070548
resource representing a document's title	Regulation of Coronaviral Poly(A) Tail Length during Infection
has PubMed Central identifier	PMC3726627
has PubMed identifier	23923003
schema:publication	PLoS One
resource representing a document's body	covid:710dd69c07a692bbdcd7261bb4508cd9935556c6#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/710dd69c07a692bbdcd7261bb4508cd9935556c6
is schema:about of	named entity 'poly(A) tail' named entity 'RNA' named entity 'poly(A)' named entity 'length' named entity 'length' named entity 'pairs' named entity 'product' named entity 'specific' named entity 'RT-PCR' named entity 'time' named entity 'parallels' named entity 'panel' named entity 'Poly(A) Tail' named entity 'Infection' covid:arg/710dd69c07a692bbdcd7261bb4508cd9935556c6 named entity 'virtue' named entity 'primers' named entity 'leader' named entity 'lengths' named entity 'expected length' named entity 'hpi' named entity 'DNA' named entity 'strand' named entity 'genome' named entity 'length' named entity 'size' named entity 'primer' named entity 'common' named entity 'control' named entity 'RT-PCR' named entity 'panel' named entity 'RT-PCR' named entity 'regulated' named entity 'Although' named entity 'RT-PCR' named entity 'strand' named entity 'RT-PCR' named entity 'translation' named entity 'sequencing' named entity 'RT-PCR' named entity 'RT-PCR' named entity 'RNA' named entity 'poly(A) tail' named entity 'poly(A) tail' named entity 'RNA' named entity 'RT-PCR' named entity 'vivo' named entity 'RT-PCR' named entity 'enhanced' named entity 'poly' named entity 'nucleotides' named entity 'specific' named entity 'poly(A) tail' named entity 'viral' named entity 'cellular' named entity 'hpi' named entity 'subgenomic mRNA' named entity 'panel' named entity 'lengths' named entity 'sequenced' named entity 'hpi' named entity 'mRNAs' named entity 'poly(A) tail' named entity 'negative strand' named entity 'viral RNA' named entity 'coronavirus' named entity 'hpi' named entity 'viral RNAs' named entity 'BCoV' named entity 'RT-PCR' named entity 'ligated' named entity 'sequenced' named entity 'polyadenylated' named entity 'poly(A) tail' named entity 'BCoV'

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