About: Epithelial Cells Derived from Swine Bone Marrow Express Stem Cell Markers and Support Influenza Virus Replication In Vitro

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Epithelial Cells Derived from Swine Bone Marrow Express Stem Cell Markers and Support Influenza Virus Replication In Vitro
Creator	Khatri, M Saif, Y
Source	PMC
abstract	The bone marrow contains heterogeneous population of cells that are involved in the regeneration and repair of diseased organs, including the lungs. In this study, we isolated and characterized progenitor epithelial cells from the bone marrow of 4- to 5-week old germ-free pigs. Microscopically, the cultured cells showed epithelial-like morphology. Phenotypically, these cells expressed the stem cell markers octamer-binding transcription factor (Oct4) and stage-specific embryonic antigen-1 (SSEA-1), the alveolar stem cell marker Clara cell secretory protein (Ccsp), and the epithelial cell markers pan-cytokeratin (Pan-K), cytokeratin-18 (K-18), and occludin. When cultured in epithelial cell growth medium, the progenitor epithelial cells expressed type I and type II pneumocyte markers. Next, we examined the susceptibility of these cells to influenza virus. Progenitor epithelial cells expressed sialic acid receptors utilized by avian and mammalian influenza viruses and were targets for influenza virus replication. Additionally, differentiated type II but not type I pneumocytes supported the replication of influenza virus. Our data indicate that we have identified a unique population of progenitor epithelial cells in the bone marrow that might have airway reconstitution potential and may be a useful model for cell-based therapies for infectious and non-infectious lung diseases.
has issue date	2011-12-22(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0029567
bibo:pmid	22216319
has license	cc-by
sha1sum (hex)	716bf47d34e36f3c165ee3c84a70d93bf6f0bf5d
schema:url	https://doi.org/10.1371/journal.pone.0029567
resource representing a document's title	Epithelial Cells Derived from Swine Bone Marrow Express Stem Cell Markers and Support Influenza Virus Replication In Vitro
has PubMed Central identifier	PMC3245290
has PubMed identifier	22216319
schema:publication	PLoS One
resource representing a document's body	covid:716bf47d34e36f3c165ee3c84a70d93bf6f0bf5d#body_text
is schema:about of	named entity 'potential' named entity 'Progenitor' named entity 'repair' named entity 'epithelial cells' named entity 'expressed' named entity 'cells' named entity 'acid' named entity 'replication' named entity 'epithelial cell' named entity 'Microscopically' named entity 'Markers' named entity 'BONE MARROW' named entity 'CONTAINS' named entity 'STEM CELL' named entity 'EXPRESSED' named entity 'MAMMALIAN' named entity 'POPULATION' named entity 'UNIQUE' named entity 'MORPHOLOGY' named entity 'INVOLVED' named entity 'CYTOKERATIN-18' named entity 'HETEROGENEOUS' named entity 'OUR' named entity 'GERM-FREE' named entity 'TYPE I' named entity 'CELLS' named entity 'TYPE II PNEUMOCYTE' named entity 'DIFFERENTIATED' named entity 'MAY BE A' named entity 'EMBRYONIC ANTIGEN' named entity 'OLD' named entity 'CULTURED CELLS' named entity 'CELL GROWTH' named entity 'ORGANS' named entity 'PAN' named entity 'SUPPORTED' named entity 'REPLICATION' named entity 'POPULATION OF CELLS' named entity 'STUDY' named entity 'MARKERS' named entity 'AIRWAY' named entity 'BONE MARROW' named entity 'BINDING' named entity 'GROWTH MEDIUM' named entity 'NON-' named entity 'IDENTIFIED' named entity 'HAVE' named entity 'SPECIFIC' named entity 'USEFUL' named entity 'DATA' named entity 'INFLUENZA VIRUSES' named entity 'STAGE' named entity 'IN VITRO' named entity 'VIRUS REPLICATION' named entity 'STEM CELL' named entity 'CYTOKERATIN' named entity 'MODEL' named entity 'INFECTIOUS' named entity 'PROGENITOR' named entity 'CLARA CELL SECRETORY PROTEIN' named entity 'TYPE II' named entity 'PNEUMOCYTES' named entity 'INFECTIOUS LUNG DISEASES' named entity 'BASED' named entity 'INFLUENZA VIRUS' named entity 'SWINE' named entity 'MARKERS' named entity 'CULTURED' named entity 'DERIVED' named entity 'EPITHELIAL CELLS' named entity 'INFLUENZA VIRUS' named entity 'SUPPORT' named entity 'VIRUS REPLICATION' named entity 'THERAPIES' named entity 'DISEASED' named entity 'ALVEOLAR' named entity 'STEM CELL MARKER' named entity 'TARGETS' named entity 'REGENERATION' named entity 'EPITHELIAL CELLS'

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