About: The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview
Creator	Amarelle, Luciano Lecuona, Emilia
Source	Medline; PMC
abstract	Since being first described more than 60 years ago, Na,K-ATPase has been extensively studied, while novel concepts about its structure, physiology, and biological roles continue to be elucidated. Cardiac glycosides not only inhibit the pump function of Na,K-ATPase but also activate intracellular signal transduction pathways, which are important in many biological processes. Recently, antiviral effects have been described as a novel feature of Na,K-ATPase inhibition with the use of cardiac glycosides. Cardiac glycosides have been reported to be effective against both DNA viruses such as cytomegalovirus and herpes simplex and RNA viruses such as influenza, chikungunya, coronavirus, and respiratory syncytial virus, among others. Consequently, cardiac glycosides have emerged as potential broad-spectrum antiviral drugs, with the great advantage of targeting cell host proteins, which help to minimize resistance to antiviral treatments, making them a very promising strategy against human viral infections. Here, we review the effect of cardiac glycosides on viral biology and the mechanisms by which these drugs impair the replication of this array of different viruses.
has issue date	2018-07-24(xsd:dateTime)
bibo:doi	10.3390/ijms19082154
bibo:pmid	30042322
has license	cc-by
sha1sum (hex)	717582da95cea3e8b268b404e9f1ecc486fff6c1
schema:url	https://doi.org/10.3390/ijms19082154
resource representing a document's title	The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview
has PubMed Central identifier	PMC6121263
has PubMed identifier	30042322
schema:publication	Int J Mol Sci
resource representing a document's body	covid:717582da95cea3e8b268b404e9f1ecc486fff6c1#body_text
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