About: The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy
Creator	Gerold, Gisa Bruening, Janina Weigel, Bettina
Source	PMC
abstract	The human interferon (IFN) response is a key innate immune mechanism to fight virus infection. IFNs are host-encoded secreted proteins, which induce IFN-stimulated genes (ISGs) with antiviral properties. Among the three classes of IFNs, type III IFNs, also called IFN lambdas (IFNLs), are an essential component of the innate immune response to hepatitis C virus (HCV). In particular, human polymorphisms in IFNL gene loci correlate with hepatitis C disease progression and with treatment response. To date, the underlying mechanisms remain mostly elusive; however it seems clear that viral infection of the liver induces IFNL responses. As IFNL receptors show a more restricted tissue expression than receptors for other classes of IFNs, IFNL treatment has reduced side effects compared to the classical type I IFN treatment. In HCV therapy, however, IFNL will likely not play an important role as highly effective direct acting antivirals (DAA) exist. Here, we will review our current knowledge on IFNL gene expression, protein properties, signaling, ISG induction, and its implications on HCV infection and treatment. Finally, we will discuss the lessons learnt from the HCV and IFNL field for virus infections beyond hepatitis C.
has issue date	2017-02-01(xsd:dateTime)
bibo:doi	10.1155/2017/7232361
bibo:pmid	28255563
has license	cc-by
sha1sum (hex)	71788152b25d71db652985de1cc4fb0513873969
schema:url	https://doi.org/10.1155/2017/7232361
resource representing a document's title	The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy
has PubMed Central identifier	PMC5309426
has PubMed identifier	28255563
schema:publication	J Immunol Res
resource representing a document's body	covid:71788152b25d71db652985de1cc4fb0513873969#body_text
is schema:about of	named entity 'side effects' named entity 'HCV' named entity 'HEPATITIS C VIRUS INFECTION' named entity 'HCV' named entity 'TISSUE EXPRESSION' named entity 'IFN' named entity 'STIMULATED' named entity 'PLAY' named entity 'DISEASE PROGRESSION' named entity 'INDUCTION' named entity 'IMMUNE' named entity 'ISG' named entity 'TYPE III' named entity 'UNDERLYING' named entity 'MECHANISM' named entity 'LIVER' named entity 'MECHANISMS' named entity 'CLASSICAL' named entity 'HUMAN' named entity 'LIKELY' named entity 'FIGHT' named entity 'PROPERTIES' named entity 'DIRECT ACTING ANTIVIRALS' named entity 'COMPONENT' named entity 'ROLE' named entity 'FIELD' named entity 'HOST' named entity 'TREATMENT' named entity 'CURRENT' named entity 'INTERFERON ' named entity 'THERAPY' named entity 'EXIST' named entity 'RESPONSE' named entity 'OTHER CLASSES' named entity 'IS A' covid:arg/71788152b25d71db652985de1cc4fb0513873969 named entity 'CLASSES' named entity 'ENCODED' named entity 'HEPATITIS C VIRUS' named entity 'LOCI' named entity 'COMPARED' named entity 'TYPE I' named entity 'SECRETED' named entity 'THERAPY' named entity 'TYPE III INTERFERONS' named entity 'ITS' named entity 'VIRUS' named entity 'HEPATITIS C' named entity 'GENE EXPRESSION' named entity 'IMPORTANT' named entity 'PARTICULAR' named entity 'OUR' named entity 'DATE' named entity 'EFFECTIVE' named entity 'DISCUSS' named entity 'POLYMORPHISMS' named entity 'CLEAR' named entity 'VIRUS INFECTION' named entity 'RESPONSES' named entity 'HIGHLY' named entity 'RESPONSE TO' named entity 'GENE' named entity 'INFECTIONS' named entity 'KNOWLEDGE' named entity 'ANTIVIRAL' named entity 'INNATE IMMUNE RESPONSE' named entity 'RESTRICTED' named entity 'ESSENTIAL' named entity 'SIGNALING' named entity 'GENES' named entity 'INDUCE' named entity 'RECEPTORS' named entity 'IFNL' named entity 'REVIEW' named entity 'HERE' named entity 'ROLE' named entity 'PROTEIN PROPERTIES' named entity 'VIRAL INFECTION' named entity 'BEYOND'

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