About: Antigen-Specific Immunotherapy for Treatment of Autoimmune Liver Diseases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antigen-Specific Immunotherapy for Treatment of Autoimmune Liver Diseases
Creator	Benichou, Gilles Chatenoud, Lucienne Stepkowski, Stanislaw Ng, Sky Richardson, Naomi Santamaria, Pere Wraith, David
Source	Medline; PMC
abstract	The liver is a critical organ in controlling immune tolerance. In particular, it is now clear that targeting antigens for presentation by antigen presenting cells in the liver can induce immune tolerance to either autoantigens from the liver itself or tissues outside of the liver. Here we review immune mechanisms active within the liver that contribute both to the control of infectious diseases and tolerance to self-antigens. Despite its extraordinary capacity for tolerance induction, the liver remains a target organ for autoimmune diseases. In this review, we compare and contrast known autoimmune diseases of the liver. Currently patients tend to receive strong immunosuppressive treatments and, in many cases, these treatments are associated with deleterious side effects, including a significantly higher risk of infection and associated health complications. We propose that, in future, antigen-specific immunotherapies are adopted for treatment of liver autoimmune diseases in order to avoid such adverse effects. We describe various therapeutic approaches that either are in or close to the clinic, highlight their mechanism of action and assess their suitability for treatment of autoimmune liver diseases.
has issue date	2020-07-21(xsd:dateTime)
bibo:doi	10.3389/fimmu.2020.01586
bibo:pmid	32793226
has license	cc-by
sha1sum (hex)	71a8bc0a9f3b1cd53dbee4d80943f99e3573a886
schema:url	https://doi.org/10.3389/fimmu.2020.01586
resource representing a document's title	Antigen-Specific Immunotherapy for Treatment of Autoimmune Liver Diseases
has PubMed Central identifier	PMC7385233
has PubMed identifier	32793226
schema:publication	Front Immunol
resource representing a document's body	covid:71a8bc0a9f3b1cd53dbee4d80943f99e3573a886#body_text
is schema:about of	named entity 'liver' named entity 'antigens' named entity 'liver' named entity 'presentation' named entity 'targeting' named entity 'complications' named entity 'autoimmune diseases' named entity 'Diseases' named entity 'autoimmune diseases' named entity 'approaches' named entity 'immunotherapies' named entity 'close' named entity 'clear' named entity 'liver' named entity 'active' named entity 'immune tolerance' named entity 'contrast' named entity 'autoimmune diseases' named entity 'Immunotherapy' named entity 'organ' named entity 'autoimmune diseases' named entity 'infectious diseases' named entity 'immunotherapies' named entity 'liver' named entity 'higher risk' named entity 'antigen' named entity 'immunosuppressive' named entity 'tolerance to self-antigens' named entity 'Autoimmune' named entity 'Specific Immunotherapy' named entity 'Antigen' named entity 'DCs' named entity 'autoantigens' named entity 'HLA-DRB1' named entity 'Th17 cells' named entity 'liver' named entity 'liver' named entity 'cytotoxicity' named entity 'CD4 T cells' named entity 'hepatic' named entity 'MHC-I' named entity 'murine models' named entity 'locus' named entity 'liver injury' named entity 'liver inflammation' named entity 'specific immunotherapy' named entity 'peptide' named entity 'cholangiocytes' named entity 'epitopes' named entity 'microsomal' named entity 'pathogenesis' named entity 'liver inflammation' named entity 'experimental animals' named entity 'Th1' named entity 'liver function' named entity 'PBC' named entity 'parenchymal' named entity 'DCs' named entity 'liver' named entity 'CYP2D6' named entity 'antigen' named entity 'PD-L1' named entity 'MHC Class II' named entity 'AIH' named entity 'secondary lymphoid tissue' named entity 'treatment options' named entity 'liver' named entity 'lymphoid organs' named entity 'small particles' named entity 'Tregs' named entity 'antigen' named entity 'bacterial infections' named entity 'sinusoids' named entity 'antibodies' named entity 'liver transplantation'

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