About: Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles
Creator	Albulescu, Lucian Strating, Jeroen Van Der Schaar, Hilde Van Kuppeveld, Frank Dorobantu, Cristina
source	Elsevier; Medline; PMC
abstract	All viruses that carry a positive-sense RNA genome (+RNA), such as picornaviruses, hepatitis C virus, dengue virus, and SARS- and MERS-coronavirus, confiscate intracellular membranes of the host cell to generate new compartments (i.e., replication organelles) for amplification of their genome. Replication organelles (ROs) are membranous structures that not only harbor viral proteins but also contain a specific array of hijacked host factors that create a unique lipid microenvironment optimal for genome replication. While some lipids may be locally synthesized de novo, other lipids are shuttled towards ROs. In picornavirus-infected cells, lipids are exchanged at membrane contact sites between ROs and other organelles. In this paper, we review recent advances in our understanding of how picornaviruses exploit host membrane contact site machinery to generate ROs, a mechanism that is used by some other +RNA viruses as well.
has issue date	2016-07-31(xsd:dateTime)
bibo:doi	10.1016/j.tim.2016.02.017
bibo:pmid	27020598
has license	els-covid
sha1sum (hex)	71c601858189dd83a4ad95f1fa1aab4f22805707
schema:url	https://doi.org/10.1016/j.tim.2016.02.017
resource representing a document's title	Fat(al) attraction: Picornaviruses Usurp Lipid Transfer at Membrane Contact Sites to Create Replication Organelles
has PubMed Central identifier	PMC7126954
has PubMed identifier	27020598
schema:publication	Trends in Microbiology
resource representing a document's body	covid:71c601858189dd83a4ad95f1fa1aab4f22805707#body_text
is schema:about of	named entity 'ATTRACTION' named entity 'CREATE' named entity 'FAT' named entity 'ORGANELLES' named entity 'PICORNAVIRUSES' named entity 'SITES' named entity 'REPLICATION' named entity 'LIPID TRANSFER' named entity 'CONTACT' named entity 'MEMBRANE' named entity 'Replication' named entity 'Fat' named entity 'enteroviruses' named entity 'ROs' named entity 'encephalitis' named entity 'clathrin-mediated endocytosis' named entity 'respiratory illness' named entity 'phosphatidylcholine' named entity 'physiological' named entity 'ACBD3' named entity 'cholesterol' named entity 'Picornaviruses' named entity 'capsid proteins' named entity 'ultrastructural' named entity 'lipid droplet' named entity 'long-chain' named entity 'protein' named entity 'Metabolism' named entity 'ROs' named entity 'enterovirus' named entity 'cholesterol' named entity 'exponential increase' named entity 'rodents' named entity 'Sac1' named entity 'ROs' named entity 'enteroviruses' named entity 'ROs' named entity 'trans-Golgi' named entity 'precursor protein' named entity 'cholesterol' named entity 'Golgi' named entity 'foot-and-mouth disease virus' named entity 'poliovirus' named entity 'GBF1' named entity 'enterovirus' named entity 'autophagy' named entity 'A71' named entity 'permeability' named entity 'Aphthovirus' named entity 'lipid' named entity 'cholesterol depletion' named entity 'Arf1' named entity 'lipid' named entity 'electron microscopy' named entity 'genus' named entity 'TBSV' named entity 'vesicles' named entity 'organelles' named entity 'lipid' named entity 'enterovirus' named entity 'MCSs' named entity 'enterovirus infection' named entity 'PI4P' named entity 'cholesterol' named entity 'ROs' named entity 'VAP' named entity 'PI4P' named entity 'PI4P' named entity 'organelles' named entity 'cell culture' named entity 'MCSs' named entity 'apoptotic cells' named entity 'phospholipids' named entity 'sphingomyelin' named entity 'plasma membrane' named entity 'MCSs' named entity 'upregulate'

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