About: Synthetic surfactin analogues have improved anti-PEDV properties

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Synthetic surfactin analogues have improved anti-PEDV properties
Creator	Li, Yuchen Zhang, Shuai Yuan, Lvfeng Peng, Jie Yangid, Qian
source	Medline; PMC
abstract	Surfactin has antiviral activity against various enveloped viruses by inhibiting viral membrane fusion. However, the potential utility of surfactin as an antiviral drug is limited by its cytotoxicity. In this study, 10 surfactin analogues were obtained by chemical synthesis and evaluated to determine their anti-PEDV activities, hemolytic activities, and critical micelle concentrations. The main goal of our study was to develop a safer drug; a surfactin analogue with high anti-PEDV activity and low hemolytic activity. Compared with surfactin, one of the analogues we developed, SLP5, has lower hemolytic activity, with the same antiviral activity. The selectivity index of SLP5 is 52, while the SI for surfactin is 4, in other words, the safe and effective concentration range of SLP5 is 12 times greater than that of surfactin. Like surfactin, SLP5 has a direct antiviral effect on PEDV. Structurally, SLP5 is a linear lipopeptide with three carboxyl groups. Surfactin derivatives similar to SLP5 could be obtained by lactone bond hydrolyzation of surfactin, as well as total synthesis.
has issue date	2019-04-11(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0215227
bibo:pmid	30973929
has license	cc-by
sha1sum (hex)	71e8fcabcecb3f5ce3a699f95a618bd21a68bd76
schema:url	https://doi.org/10.1371/journal.pone.0215227
resource representing a document's title	Synthetic surfactin analogues have improved anti-PEDV properties
has PubMed Central identifier	PMC6459484
has PubMed identifier	30973929
schema:publication	PLoS One
resource representing a document's body	covid:71e8fcabcecb3f5ce3a699f95a618bd21a68bd76#body_text
is schema:about of	named entity 'antiviral' named entity 'cytotoxicity' named entity 'developed' named entity 'direct' named entity 'antiviral' named entity 'PEDV' named entity 'POTENTIAL' named entity 'UTILITY' named entity 'INHIBITING' named entity 'ANTIVIRAL ACTIVITY' named entity 'TIMES' named entity 'SYNTHETIC' named entity 'LIMITED BY' named entity 'STUDY' named entity 'CHEMICAL SYNTHESIS' named entity 'LACTONE' named entity 'LIPOPEPTIDE' named entity 'COMPARED' named entity 'VIRAL MEMBRANE' named entity 'OBTAINED BY' named entity 'ITS' named entity 'HEMOLYTIC ACTIVITY' named entity 'PEDV' named entity 'SURFACTIN' named entity 'HIGH' named entity 'WORDS' named entity 'SURFACTIN' named entity 'MAIN' named entity 'TOTAL SYNTHESIS' named entity 'MEMBRANE FUSION' named entity 'MICELLE' named entity 'SELECTIVITY' named entity 'DETERMINE' named entity 'HEMOLYTIC' named entity 'GOAL' named entity 'DIRECT' named entity 'ANALOGUE' named entity 'SIMILAR' named entity 'RANGE' named entity 'EFFECT' named entity 'CONCENTRATIONS' named entity 'LIKE' named entity 'EVALUATED' named entity 'EFFECTIVE' named entity 'THEIR' named entity 'SLP5' named entity 'VARIOUS' named entity 'ONE OF' named entity 'COULD BE' named entity 'IS A' named entity 'INDEX' named entity 'LOW' named entity 'OUR' named entity 'DRUG' named entity 'LOWER' named entity 'ANTIVIRAL' named entity 'CARBOXYL' named entity 'ACTIVITIES' named entity 'ANTIVIRAL DRUG' named entity 'CONCENTRATION' named entity 'SAFE' named entity 'BOND' named entity 'ACTIVITY' named entity 'GROUPS' named entity 'PROPERTIES' named entity 'HAVE' named entity 'GREATER THAN' named entity 'LINEAR' named entity 'CRITICAL' named entity 'IMPROVED' named entity 'CYTOTOXICITY' named entity 'VIRUSES' covid:arg/71e8fcabcecb3f5ce3a699f95a618bd21a68bd76 named entity 'activity' named entity 'effective concentration' named entity 'develop' named entity 'hydrolyzation'

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