About: Mechanism of Cxc Chemokine Ligand 5 (CXCL5)/Cxc Chemokine Receptor 2 (CXCR2) Bio-Axis in Mice with Acute Respiratory Distress Syndrome

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About: Mechanism of Cxc Chemokine Ligand 5 (CXCL5)/Cxc Chemokine Receptor 2 (CXCR2) Bio-Axis in Mice with Acute Respiratory Distress Syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Mechanism of Cxc Chemokine Ligand 5 (CXCL5)/Cxc Chemokine Receptor 2 (CXCR2) Bio-Axis in Mice with Acute Respiratory Distress Syndrome
Creator	Shang, Min Hu, Ke Acdef, Feng, Li-Zhi Wang, Chang-Yong Zhou, Chen-Liang Zhou, Qing-Shan
topic	covid:725f0a6590f20c15be0ae719463c0624a34ee1af#this
Source	PMC
abstract	BACKGROUND: Acute respiratory distress syndrome (ARDS) is a common acute and severe disease in clinic. Recent studies indicated that Cxc chemokine ligand 5 (CXCL5), an inflammatory chemokine, was associated with tumorigenesis. The present study investigated the role of the CXCL5/Cxc chemokine receptor 2 (CXCR2) bio-axis in ARDS, and explored the underlying molecular mechanism. MATERIAL/METHODS: The pathological morphology of lung tissue and degree of pulmonary edema were assessed by hematoxylin-eosin staining and pulmonary edema score, respectively. Real-time PCR and Western blot analysis were performed to detect the expression levels of CXCL5, CXCR2, Matrix metalloproteinases 2 (MMP2), and Matrix metalloproteinases 9 (MMP9) in lung tissues. Enzyme-linked immunosorbent assay (ELISA) was performed to determine the expression levels of CXCL5 and inflammatory factors (IL-1β, IL-6, TNF-α, and IL-10) in serum. RESULTS: The results demonstrated that diffuse alveolar damage and pulmonary edema appeared in lipopolysaccharide (LPS)-induced ARDS and were positively correlated with the severity of ARDS. In addition, CXCL5 and its receptor CXCR2 were overexpressed by upregulation of MMP2 and MMP9 in lung tissues of ARDS. In addition, CXCL5 neutralizing antibody effectively alleviated inflammatory response, diffuse alveolar damage, and pulmonary edema, and decreased the expression levels of MMP2 and MMP9 compared to LPS-induced ARDS. CONCLUSIONS: We found that CXCL5/CXCR2 accelerated the progression of ARDS, partly by upregulation of MMP2 and MMP9 in lung tissues with the release of inflammatory factors.
has issue date	2019-07-17(xsd:dateTime)
bibo:doi	10.12659/msm.915835
bibo:pmid	31311916
has license	cc-by-nc-nd
sha1sum (hex)	725f0a6590f20c15be0ae719463c0624a34ee1af
schema:url	https://doi.org/10.12659/msm.915835
resource representing a document's title	Mechanism of Cxc Chemokine Ligand 5 (CXCL5)/Cxc Chemokine Receptor 2 (CXCR2) Bio-Axis in Mice with Acute Respiratory Distress Syndrome
has PubMed Central identifier	PMC6659456
has PubMed identifier	31311916
schema:publication	Med Sci Monit
resource representing a document's body	covid:725f0a6590f20c15be0ae719463c0624a34ee1af#body_text
is http://vocab.deri.ie/void#inDataset of	proxy:http/ns.inria.fr/covid19/725f0a6590f20c15be0ae719463c0624a34ee1af
is schema:about of	named entity 'LICENSED' named entity 'INDICATED' named entity 'ACUTE' named entity 'INFLAMMATORY CHEMOKINE' named entity 'INVESTIGATED' named entity 'ROLE' named entity 'A COMMON' named entity 'ARDS' named entity 'STUDY' named entity 'STUDIES' named entity 'CXCR2' covid:arg/725f0a6590f20c15be0ae719463c0624a34ee1af named entity 'NC-' named entity 'SEVERE DISEASE' named entity 'CXCL5' named entity 'CXC CHEMOKINE' named entity 'WORK' named entity 'MICE' named entity 'MECHANISM' named entity 'INTERNATIONAL' named entity 'AXIS' named entity 'ATTRIBUTION' named entity 'TUMORIGENESIS' named entity 'IS A' named entity 'RECENT' named entity 'UNDERLYING' named entity 'CHEMOKINE RECEPTOR' named entity 'COMMON' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'AXIS' named entity 'MOLECULAR MECHANISM' named entity 'CHEMOKINE LIGAND 5' named entity 'CXC CHEMOKINE' named entity 'CLINIC' named entity 'ASSOCIATED WITH' named entity 'ACUTE RESPIRATORY DISTRESS SYNDROME' named entity 'PRESENT' named entity 'CHEMOKINE LIGAND 5' named entity 'CHEMOKINE RECEPTOR' named entity 'Recent' named entity 'CXCR2' named entity 'Cxc Chemokine Receptor' named entity 'CXCR2' named entity 'molecular mechanism' named entity 'CXCL5' named entity 'ARDS' named entity 'Acute respiratory distress syndrome' named entity 'CXCL5' named entity 'CXCL10' named entity 'LPS' named entity 'pulmonary edema' named entity 'ARDS' named entity 'normal saline' named entity 'CXCR2' named entity 'centrifugation' named entity 'MMP9' named entity 'ARDS' named entity 'ethanol' named entity 'oncogenic' named entity 'China' named entity 'China' named entity 'dyspnea' named entity 'ARDS' named entity 'lung cancer' named entity 'Billerica' named entity 'GPCR' named entity 'ARDS' named entity 'CXCR2' named entity 'Zhejiang' named entity 'Western blot' named entity 'CXCL5' named entity 'hematoxylin' named entity 'Guangzhou'

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