About: Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection

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About: Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection
Creator	Berard, A Cortens, J Krokhin, O Severini, A Wilkins, J
topic	covid:72613cfcf7d9ce3ba6d87fa24e2c220a15914d73#this
Source	Medline; PMC
abstract	All viruses are dependent upon host cells for replication. Infection can induce profound changes within cells, including apoptosis, morphological changes, and activation of signaling pathways. Many of these alterations have been analyzed by gene arrays to measure the cellular “transcriptome.” We used SILAC (stable isotope labeling by amino acids in cell culture), combined with high-throughput 2-D HPLC/mass spectrometry, to determine relative quantitative differences in host proteins at 6 and 24 hours after infecting HEK293 cells with reovirus serotype 1 Lang (T1L). 3,076 host proteins were detected at 6hpi, of which 132 and 68 proteins were significantly up or down regulated, respectively. 2,992 cellular proteins, of which 104 and 49 were up or down regulated, respectively, were identified at 24hpi. IPA and DAVID analyses indicated proteins involved in cell death, cell growth factors, oxygen transport, cell structure organization and inflammatory defense response to virus were up-regulated, whereas proteins involved in apoptosis, isomerase activity, and metabolism were down-regulated. These proteins and pathways may be suitable targets for intervention to either attenuate virus infection or enhance oncolytic potential.
has issue date	2012-12-11(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0051939
bibo:pmid	23240068
has license	cc-by
sha1sum (hex)	72613cfcf7d9ce3ba6d87fa24e2c220a15914d73
schema:url	https://doi.org/10.1371/journal.pone.0051939
resource representing a document's title	Quantification of the Host Response Proteome after Mammalian Reovirus T1L Infection
has PubMed Central identifier	PMC3519901
has PubMed identifier	23240068
schema:publication	PLoS One
resource representing a document's body	covid:72613cfcf7d9ce3ba6d87fa24e2c220a15914d73#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/72613cfcf7d9ce3ba6d87fa24e2c220a15914d73
is schema:about of	named entity 'replication' named entity 'identified' named entity 'SILAC' named entity 'analyses' named entity 'structure' named entity 'host' named entity 'HOST RESPONSE' named entity 'APOPTOSIS' named entity 'GENE ARRAYS' named entity 'MAY BE' named entity 'CELL DEATH' named entity 'SPECTROMETRY' named entity 'THESE' named entity 'PATHWAYS' named entity 'POTENTIAL' named entity 'CELL STRUCTURE' named entity 'CHANGES' named entity 'REOVIRUS' named entity 'SIGNALING PATHWAYS' named entity 'ISOMERASE ACTIVITY' named entity 'QUANTITATIVE' named entity 'LANG' named entity 'EITHER' named entity 'IDENTIFIED' named entity 'HEK293 CELLS' named entity 'VIRUS INFECTION' named entity 'RELATIVE' named entity 'INTERVENTION' named entity 'TO MEASURE' named entity 'DAVID' named entity 'INDICATED' named entity '24 HOURS' named entity '2-D' named entity 'DEPENDENT' named entity 'ENHANCE' named entity 'DETECTED' named entity 'INFLAMMATORY' named entity 'HPLC' named entity 'COMBINED' named entity 'HOST' named entity 'IPA' named entity 'CELLS' named entity 'ALTERATIONS' named entity '104' named entity 'ISOTOPE LABELING' named entity 'PROTEINS' named entity 'UP-REGULATED' named entity 'DOWN REGULATED' named entity '2C076' named entity 'USED' named entity 'SILAC' named entity 'PROTEOME' named entity 'INFECTION' named entity 'T1L' named entity 'MAMMALIAN REOVIRUS' named entity 'ATTENUATE' named entity 'TARGETS' named entity 'ONCOLYTIC' named entity 'INCLUDING' named entity 'CELL CULTURE' covid:arg/72613cfcf7d9ce3ba6d87fa24e2c220a15914d73 named entity 'PROFOUND' named entity 'SEROTYPE' named entity 'MORPHOLOGICAL' named entity 'CELL GROWTH' named entity '2C CELL' named entity '132' named entity 'CELLULAR' named entity 'THROUGHPUT' named entity 'HOST CELLS' named entity 'ANALYZED' named entity 'INFECTING' named entity 'REPLICATION' named entity 'INDUCE' named entity 'DETERMINE'

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