About: Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese
Creator	Zeng, Yi-Xin Zhang, Ying Bei, Jinxin Cao, Pengbo Cui, Ying Guo, Bingqian He, Fuchu Hu, Yanling Hu, Zhibin Li, Yuanfeng Liu, Guanjun Liu, Xiaomin Liu, Xinyi Lu, Hui Mo, Zengnan Ping, Jie Ren, Qian Shen, Hongbing Wu, Miantao Xie, Bobo Yu, Yinghua Zhai, Yun Zhang, Haitao Zhang, Hongxing Zhou, Gangqiao
Source	Medline; PMC
abstract	The sodium taurocholate cotransporting polypeptide (NTCP) encoded by SLC10A1 was recently demonstrated to be a functional receptor for hepatitis B virus (HBV). The role of SLC10A1 polymorphisms, particularly the Ser267Phe variant (rs2296651) in exon 4, has been frequently investigated in regard to risk of persistent HBV infection. However, these investigations have generated conflicting results. To examine whether common genetic variation at the SLC10A1 locus is associated with risk of persistent HBV infection, haplotype-tagging and imputed single nucleotide polymorphisms (SNPs) were assessed in two case-control sample sets, totally including 2,550 cases (persistently HBV infected subjects, PIs) and 2,124 controls (spontaneously recovered subjects, SRs) of Southern Chinese ancestry. To test whether rare or subpolymorphic SLC10A1 variants are associated with disease risk, the gene’s exons in 244 cases were sequenced. Overall, we found neither SNPs nor haplotypes of SLC10A1 showed significant association in the two sample sets. Furthermore, no significant associations of rare variants or copy number variation covering SLC10A1 were observed. Finally, expression quantitative trait locus analyses revealed that SNPs potentially affecting SLC10A1 expression also showed no significant associations. We conclude that genetic variation at the SLC10A1 locus is not likely a major risk factor of persistent HBV infection among Southern Chinese.
has issue date	2017-04-21(xsd:dateTime)
bibo:doi	10.1038/srep46490
bibo:pmid	28429786
has license	cc-by
sha1sum (hex)	7267644046c69d176e889933002a9c8819751ff8
schema:url	https://doi.org/10.1038/srep46490
resource representing a document's title	Comprehensive assessment showed no associations of variants at the SLC10A1 locus with susceptibility to persistent HBV infection among Southern Chinese
has PubMed Central identifier	PMC5399367
has PubMed identifier	28429786
schema:publication	Sci Rep
resource representing a document's body	covid:7267644046c69d176e889933002a9c8819751ff8#body_text
is schema:about of	named entity 'HBV INFECTION' named entity 'infection' named entity 'risk factor' named entity 'SRs' named entity 'recovered' named entity 'imputed' named entity 'copy number variation' named entity 'hepatitis B virus' named entity 'SLC10A1' named entity 'CONTROLS' named entity 'ASSESSMENT' named entity 'INVESTIGATED' named entity 'RECEPTOR' named entity 'LIKELY' named entity 'RECOVERED' named entity 'HBV INFECTION' named entity 'SAMPLE' named entity 'CONTROL SAMPLE' named entity 'HBV' named entity 'SOUTHERN' named entity 'INCLUDING' named entity '244' named entity 'EXPRESSION QUANTITATIVE TRAIT LOCUS' named entity 'VARIANT' named entity 'ASSESSED' named entity 'THESE' named entity 'PERSISTENT' named entity 'FUNCTIONAL' named entity 'DISEASE RISK' named entity 'RESULTS' named entity 'ROLE' named entity 'REGARD' named entity 'SODIUM TAUROCHOLATE' named entity 'REVEALED' named entity 'OBSERVED' named entity '27S' named entity 'CASE-CONTROL' named entity 'A MAJOR' named entity 'ENCODED' named entity 'RECENTLY' named entity 'COMMON' named entity 'POLYMORPHISMS' named entity 'HAVE' named entity 'ASSOCIATIONS' named entity 'GENERATED' named entity 'ASSOCIATED WITH' named entity 'TAGGING' named entity 'ASSOCIATIONS' named entity 'SUSCEPTIBILITY' named entity 'HAPLOTYPE' named entity 'GENE' named entity 'INVESTIGATIONS' named entity 'SRS' named entity 'CHINESE' named entity 'FREQUENTLY' named entity 'OVERALL' named entity 'CHINESE'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software