About: Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication
Creator	Li, Yan Yang, Ling Wang, Xia Wang, Yonghua Li, Bohui Li, Xiuxiu Tao, Weiyang Xu, Xue
Source	Medline; PMC
abstract	Given the imminent threat of influenza pandemics and continuing emergence of new drug-resistant influenza virus strains, novel strategies for preventing and treating influenza disease are urgently needed. Herbal medicine, used for thousands of years in combinational therapies (Herb Formula), plays a significant role in stimulating the host immune system in vivo, and meanwhile, in fighting against the pandemic by directly inhibiting influenza virus in vitro. Such potential Janus functions may spark interest in therapeutic manipulation of virus diseases. Unfortunately, the molecular mechanism of the Janus functions of the medicinal herbs in the treatment of influenza remains unclear. In this work, to illustrate the therapeutic concept of Janus functions in the treatment of influenza, we have introduced a novel systems pharmacology model that integrates pharmacokinetic screening, targeting and network analysis of two representative herbs Lonicera japonica and Fructus Forsythiae that are efficient in the treatment of influenza, inflammation and other diseases. 50 Chemicals with favorable pharmacokinetic profiles have been identified for the two herbs, and the ligand–target network was constructed by complementing the literature-based experimental data deposited in DrugBank. The annotation of these chemicals was assigned using a novel drug targeting approach, and mapped to target–disease and drug–target–pathway networks. The overall data suggest that the medicinal herbs function by indirectly suppressing the virus proliferation via regulating the immune systems in hosts, and also, by directly inhibiting virus proliferation through targeting viral proteins essential for the viral life cycle. For the first time, we have demonstrated the mechanism of medicinal herbs in prevention and treatment of virus diseases via the Janus functions on a systematic level.
has issue date	2012-11-20(xsd:dateTime)
bibo:doi	10.1039/c2ib20204b
bibo:pmid	23168537
has license	no-cc
sha1sum (hex)	7269b61f6452772b2222cf80e492d093e0e75bc1
schema:url	https://doi.org/10.1039/c2ib20204b
resource representing a document's title	Systems pharmacology uncovers Janus functions of botanical drugs: activation of host defense system and inhibition of influenza virus replication
has PubMed Central identifier	PMC7108588
has PubMed identifier	23168537
schema:publication	Integr Biol (Camb)
resource representing a document's body	covid:7269b61f6452772b2222cf80e492d093e0e75bc1#body_text
is schema:about of	named entity 'BOTANICAL' named entity 'pandemics' named entity 'inhibition' named entity 'host defense' covid:arg/7269b61f6452772b2222cf80e492d093e0e75bc1 named entity 'SYSTEM' named entity 'ACTIVATION' named entity 'IMMINENT' named entity 'INFLUENZA' named entity 'EMERGENCE' named entity '80%' named entity 'STRAINS' named entity 'THREAT' named entity 'VIRUS REPLICATION' named entity 'HOST DEFENSE' named entity 'FUNCTIONS' named entity 'PHARMACOLOGY' named entity 'INFLUENZA VIRUS' named entity 'DRUGS' named entity 'SYSTEMS' named entity 'RESISTANT' named entity 'STRATEGIES' named entity 'JANUS' named entity 'NEW DRUG' named entity 'INHIBITION' named entity 'INFLUENZA VIRUS' named entity 'NOVEL' named entity 'PANDEMICS' named entity 'PREVENTING' named entity 'CONTINUING' named entity 'NEEDED' named entity 'GIVEN' named entity 'TREATING' named entity 'DISEASE' named entity 'infection' named entity 'protein' named entity 'Fructus' named entity 'influenza' named entity 'virus' named entity 'mechanisms of action' named entity 'infection' named entity 'environmental factors' named entity 'pathogens' named entity 'influenza' named entity 'hyperforin' named entity 'epi' named entity 'ligand' named entity 'essential oils' named entity 'herbal medicines' named entity 'Fructus' named entity 'headache' named entity 'Swiss-Model' named entity 'infection' named entity 'Fructus' named entity 'Lonicera japonica' named entity '3D structures' named entity 'CDK2' named entity 'active form' named entity 'Influenza pandemics' named entity 'influenza' named entity 'immunodeficiency' named entity 'biological pathway' named entity 'dose-dependent' named entity 'toxicity' named entity 'SVM' named entity 'immunomodulatory' named entity 'cis-jasmone' named entity 'Chinese herb' named entity 'herbal medicine' named entity 'H1N1 flu' named entity 'high fever' named entity 'viral infection' named entity 'Lonicera japonica' named entity 'Protein'

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