About: Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection

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About: Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection
Creator	Drosten, Christian Aldabbagh, Souhaib Rambaut, Andrew Dittmer, Ulf Muth, Doreen Gold, Hermann Graf, Petra Haas, Walter Seilmaier, Michael Wendtner, Clemens-Martin Junglen, Sandra Kallies, Rene Bonin, Frank Guberina, Hana Guggemos, Wolfgang Hartmann, Wulf Röhnisch, Tim Sack, Stefan Scheible, Gregor Schmid-Wendtner, Monika Müller, Marcel Corman, Victor
Source	Elsevier; Medline; PMC
abstract	Summary Background The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus involved in cases and case clusters of severe acute respiratory infection in the Arabian Peninsula, Tunisia, Morocco, France, Italy, Germany, and the UK. We provide a full description of a fatal case of MERS-CoV infection and associated phylogenetic analyses. Methods We report data for a patient who was admitted to the Klinikum Schwabing (Munich, Germany) for severe acute respiratory infection. We did diagnostic RT-PCR and indirect immunofluorescence. From time of diagnosis, respiratory, faecal, and urine samples were obtained for virus quantification. We constructed a maximum likelihood tree of the five available complete MERS-CoV genomes. Findings A 73-year-old man from Abu Dhabi, United Arab Emirates, was transferred to Klinikum Schwabing on March 19, 2013, on day 11 of illness. He had been diagnosed with multiple myeloma in 2008, and had received several lines of treatment. The patient died on day 18, due to septic shock. MERS-CoV was detected in two samples of bronchoalveolar fluid. Viral loads were highest in samples from the lower respiratory tract (up to 1·2 × 106 copies per mL). Maximum virus concentration in urine samples was 2691 RNA copies per mL on day 13; the virus was not present in the urine after renal failure on day 14. Stool samples obtained on days 12 and 16 contained the virus, with up to 1031 RNA copies per g (close to the lowest detection limit of the assay). One of two oronasal swabs obtained on day 16 were positive, but yielded little viral RNA (5370 copies per mL). No virus was detected in blood. The full virus genome was combined with four other available full genome sequences in a maximum likelihood phylogeny, correlating branch lengths with dates of isolation. The time of the common ancestor was halfway through 2011. Addition of novel genome data from an unlinked case treated 6 months previously in Essen, Germany, showed a clustering of viruses derived from Qatar and the United Arab Emirates. Interpretation We have provided the first complete viral load profile in a case of MERS-CoV infection. MERS-CoV might have shedding patterns that are different from those of severe acute respiratory syndrome and so might need alternative diagnostic approaches. Funding European Union; German Centre for Infection Research; German Research Council; and German Ministry for Education and Research.
has issue date	2013-09-30(xsd:dateTime)
bibo:doi	10.1016/s1473-3099(13)70154-3
bibo:pmid	23782859
has license	els-covid
sha1sum (hex)	726d2a800d647df7d36c8395fafff53fc2ed169a
schema:url	https://doi.org/10.1016/s1473-3099%2813%2970154-3
resource representing a document's title	Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection
has PubMed Central identifier	PMC7164791
has PubMed identifier	23782859
schema:publication	The Lancet Infectious Diseases
resource representing a document's body	covid:726d2a800d647df7d36c8395fafff53fc2ed169a#body_text
is schema:about of	named entity 'ANALYSIS' named entity 'France' named entity 'CLINICAL FEATURES' named entity 'CASE' named entity 'ITALY' named entity 'ASSOCIATED' named entity 'ARABIAN PENINSULA' named entity 'MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS' named entity 'VIROLOGICAL' named entity 'CORONAVIRUS INFECTION' named entity 'MOROCCO' named entity 'TUNISIA' named entity 'CASE' named entity 'ARTICLES' named entity 'INFECTION' named entity 'SEVERE ACUTE RESPIRATORY INFECTION' named entity 'GERMANY' named entity 'DESCRIPTION' named entity 'MERS-COV' named entity 'FATAL' named entity 'PROVIDE' named entity 'CLUSTERS' named entity 'FRANCE' covid:arg/726d2a800d647df7d36c8395fafff53fc2ed169a named entity 'infection' named entity 'Morocco' named entity 'case' named entity 'case' named entity 'phylogenetic analyses' named entity 'virological' named entity 'infection' named entity 'Middle East respiratory syndrome coronavirus' named entity 'genome sequences' named entity 'serum samples' named entity 'Penzberg' named entity 'intensive care unit' named entity 'Germany' named entity 'rhinovirus' named entity 'diagnostic tests' named entity 'human coronavirus' named entity 'sequence data' named entity 'virus' named entity 'immunopathogenesis' named entity 'primer design' named entity 'MERS-CoV' named entity 'Virus' named entity 'catheters' named entity 'tracheobronchial' named entity 'Diarrhoea' named entity 'infection' named entity 'follow-up' named entity 'Germany' named entity 'health-care' named entity 'negative result' named entity 'cell culture' named entity 'IgM' named entity 'GenBank' named entity 'MERS-CoV' named entity 'vascular endothelial cells' named entity 'stool sample'

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