About: Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation

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About: Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation
Creator	Cai, Xiaojun Dai, Hanjun Ke, Min Liu, Zeming Luo, Hong Yan, Ming Zeng, Wen
Source	PMC
abstract	The epigenetic silencing of tumor suppressor genes in myelodysplastic syndromes (MDS) can potentially confer a growth advantage to individual cellular clones. Currently, the recommended treatment for patients with high-risk MDS is the methylation agent decitabine (DAC), a drug that can induce the reexpression of silenced tumor suppressor genes. We investigated the effects of DAC treatment on the myeloid MDS cell line SKM-1 and investigated the role of FOXO3A, a potentially tumor-suppressive transcription factor, by silencing its expression prior to DAC treatment. We found that FOXO3A exists in an inactive, hyperphosphorylated form in SKM-1 cells, but that DAC both induces FOXO3A expression and reactivates the protein by reducing its phosphorylation level. Furthermore, we show that this FOXO3A activation is responsible for the DAC-induced differentiation of SKM-1 cells into monocytes, as well as for SKM-1 cell cycle arrest, apoptosis, and autophagy. Collectively, these results suggest that FOXO3A reactivation may contribute to the therapeutic effects of DAC in MDS.
has issue date	2017-10-16(xsd:dateTime)
bibo:doi	10.1155/2017/4302320
bibo:pmid	29124072
has license	cc-by
sha1sum (hex)	72a5995cb9dc08122a069c6b02e72f2894e0b07c
schema:url	https://doi.org/10.1155/2017/4302320
resource representing a document's title	Decitabine-Induced Changes in Human Myelodysplastic Syndrome Cell Line SKM-1 Are Mediated by FOXO3A Activation
has PubMed Central identifier	PMC5662805
has PubMed identifier	29124072
schema:publication	J Immunol Res
resource representing a document's body	covid:72a5995cb9dc08122a069c6b02e72f2894e0b07c#body_text
is schema:about of	covid:arg/72a5995cb9dc08122a069c6b02e72f2894e0b07c named entity 'decitabine' named entity 'clones' named entity 'cell line' named entity 'epigenetic silencing' named entity 'monocytes' named entity 'MDS' named entity 'myelodysplastic syndromes' named entity 'MDS' named entity 'FOXO3A' named entity 'ethanol' named entity 'standard deviation' named entity 'cellular differentiation' named entity 'double-stranded DNA' named entity 'cell cycle arrest' named entity 'China' named entity 'CDKN1B' named entity 'FOXO3A' named entity 'upregulation' named entity 'DNA repair' named entity 'ATG5' named entity 'epigenetic' named entity 'CDKN1B' named entity 'MYC' named entity 'LC3' named entity 'phosphorylated' named entity 'Thermo Fisher Scientific' named entity 'cell cycle' named entity 'MDS' named entity 'CST' named entity 'MYC' named entity 'glycine' named entity 'human plasma' named entity 'FOXO3A' named entity 'cell line' named entity 'Tongji Hospital' named entity 'autophagy' named entity 'apoptotic cells' named entity 'siRNA' named entity 'CDKN1B' named entity 'LC3' named entity 'MXI1' named entity 'protein expression' named entity 'metabolic' named entity 'apoptosis' named entity 'CD14' named entity 'BCL2L11' named entity 'CDKN1B' named entity 'conjugated' named entity 'drug-induced' named entity 'FOXO3A' named entity '37°C' named entity 'CDKN1A' named entity 'LC3' named entity 'FASLG' named entity 'ATM' named entity 'cell death' named entity 'growth phase' named entity 'CD14' named entity 'gene silencing' named entity 'stress responses' named entity 'protein' named entity 'MYC' named entity 'forkhead' named entity 'tumors' named entity 'apoptosis' named entity 'FOXO3A' named entity 'upregulation' named entity 'ethanol' named entity 'upregulation' named entity 'apoptosis' named entity 'methyltransferase' named entity 'hematopoiesis' named entity 'cell survival' named entity 'upregulate'

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