About: Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome

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About: Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome
Creator	Hsu, Li-Yang Jayapal, Manikandan Reghunathan, Renji Chng, Hiok-Hee Tai, Dessmon Leung, Bernard Melendez, Alirio
Source	Medline; PMC
abstract	BACKGROUND: Severe acute respiratory syndrome (SARS) emerged in later February 2003, as a new epidemic form of life-threatening infection caused by a novel coronavirus. However, the immune-pathogenesis of SARS is poorly understood. To understand the host response to this pathogen, we investigated the gene expression profiles of peripheral blood mononuclear cells (PBMCs) derived from SARS patients, and compared with healthy controls. RESULTS: The number of differentially expressed genes was found to be 186 under stringent filtering criteria of microarray data analysis. Several genes were highly up-regulated in patients with SARS, such as, the genes coding for Lactoferrin, S100A9 and Lipocalin 2. The real-time PCR method verified the results of the gene array analysis and showed that those genes that were up-regulated as determined by microarray analysis were also found to be comparatively up-regulated by real-time PCR analysis. CONCLUSIONS: This differential gene expression profiling of PBMCs from patients with SARS strongly suggests that the response of SARS affected patients seems to be mainly an innate inflammatory response, rather than a specific immune response against a viral infection, as we observed a complete lack of cytokine genes usually triggered during a viral infection. Our study shows for the first time how the immune system responds to the SARS infection, and opens new possibilities for designing new diagnostics and treatments for this new life-threatening disease.
has issue date	2005-01-18(xsd:dateTime)
bibo:doi	10.1186/1471-2172-6-2
bibo:pmid	15655079
has license	cc-by
sha1sum (hex)	72ace5af731fdf4c384e912b074193d13902b7a1
schema:url	https://doi.org/10.1186/1471-2172-6-2
resource representing a document's title	Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome
has PubMed Central identifier	PMC546205
has PubMed identifier	15655079
schema:publication	BMC Immunol
resource representing a document's body	covid:72ace5af731fdf4c384e912b074193d13902b7a1#body_text
is schema:about of	named entity 'PBMCs' named entity 'peripheral blood mononuclear cells' named entity 'GENES' covid:arg/72ace5af731fdf4c384e912b074193d13902b7a1 named entity 'CAUSED BY' named entity 'HOST RESPONSE' named entity 'DERIVED' named entity 'SARS' named entity 'PATHOGENESIS' named entity 'INFECTION' named entity 'HEALTHY' named entity 'PERIPHERAL BLOOD MONONUCLEAR CELLS' named entity 'NOVEL CORONAVIRUS' named entity 'UNDERSTOOD' named entity 'LATER' named entity 'EXPRESSION PROFILE' named entity 'PATIENTS' named entity 'NEW' named entity 'IMMUNE RESPONSE' named entity 'PATIENTS' named entity 'INVESTIGATED' named entity 'PATHOGEN' named entity 'IMMUNE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'BMC' named entity 'IMMUNOLOGY' named entity 'RESPONSE TO' named entity 'COMPARED' named entity 'UNDERSTAND' named entity 'FORM' named entity 'GENE EXPRESSION PROFILES' named entity 'LIFE' named entity 'SEVERE ACUTE RESPIRATORY SYNDROME' named entity 'FEBRUARY' named entity 'EPIDEMIC' named entity 'POORLY' named entity 'BACKGROUND' named entity 'February' named entity 'patients' named entity 'epidemic' named entity 'Expression' named entity 'PBMCs' named entity 'life-threatening infection' named entity 'BMC Immunology' named entity 'C-C motif' named entity 'S100A9' named entity 'inflammatory response' named entity 'SARS' named entity 'gene' named entity 'Receptor' named entity 'SARS' named entity 'antibody' named entity 'St. Louis' named entity 'upregulation' named entity 'SARS-CoV' named entity 'microarrays' named entity 'CD8+ T cells' named entity 'intensive care' named entity 'microarray' named entity 'cytokines' named entity 'parturition' named entity 'formamide' named entity 'nuclear translocation' named entity 'lymphocytes' named entity 'cDNA' named entity 'NK cells' named entity 'cytolytic activity' named entity 'Gene Chip' named entity 'PBMCs' named entity 'TLR2' named entity 'World Health Organization' named entity 'receptor' named entity 'WHO' named entity 'Lactoferrin' named entity 'hybridization'

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