About: A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection

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About: A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection Goto Sponge NotDistinct Permalink

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection
Creator	Hou, Yixuan Baric, Ralph Gralinski, Lisa Zhao, Haiyan Diamond, Michael Case, James Curiel, David Dai, Fox, Julie Fremont, Daved Hassan, Ahmed Kim, Arthur Vanblargan, Laura Dmitriev, Igor Holtzman, Michael Mccune, Broc Winkler, Emma Kafai, Natasha Bailey, Adam Chen, Rita Keeler, Shamus Shrihari, Swathi Smith, Brittany Weiskopf, Daniela Adams, Lucas Kashentseva, Ma, Meisheng Schaefer, Alexandra Wessel, Alex Yanan,
Source	BioRxiv
abstract	The Coronavirus Disease 2019 pandemic has made deployment of an effective vaccine a global health priority. We evaluated the protective activity of a chimpanzee adenovirus-vectored vaccine encoding a pre-fusion stabilized spike protein (ChAd-SARS-CoV-2-S) in challenge studies with Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mice expressing the human angiotensin-converting enzyme 2 receptor. Intramuscular dosing of ChAd-SARS-CoV-2-S induces robust systemic humoral and cell-mediated immune responses and protects against lung infection, inflammation, and pathology but does not confer sterilizing immunity, as evidenced by detection of viral RNA and induction of anti-nucleoprotein antibodies after SARS-CoV-2 challenge. In contrast, a single intranasal dose of ChAd-SARS-CoV-2-S induces high levels of systemic and mucosal IgA and T cell responses, completely prevents SARS-CoV-2 infection in the upper and lower respiratory tracts, and likely confers sterilizing immunity in most animals. Intranasal administration of ChAd-SARS-CoV-2-S is a candidate for preventing SARS-CoV-2 infection and transmission, and curtailing pandemic spread.
has issue date	2020-07-17(xsd:dateTime)
bibo:doi	10.1101/2020.07.16.205088
has license	biorxiv
sha1sum (hex)	72bd0d9ac417b403d0ad136c4f83333bb1553973
schema:url	https://doi.org/10.1101/2020.07.16.205088
resource representing a document's title	A single intranasal dose of chimpanzee adenovirus-vectored vaccine confers sterilizing immunity against SARS-CoV-2 infection
schema:publication	bioRxiv
resource representing a document's body	covid:72bd0d9ac417b403d0ad136c4f83333bb1553973#body_text
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