About: An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titration

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About: An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titration Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titration
Creator	Nelson, Eric Anbalagan, Srivishnupriya Okda, Faten Batman, Ron Hause, Ben Collin, Emily
source	Medline; PMC
abstract	BACKGROUND: Porcine epidemic diarrhea virus (PEDV), a highly pathogenic and transmissible virus in swine, was first detected in the U.S. in May, 2013, and has caused tremendous losses to the swine industry. Due to the difficulty in isolating and growing this virus in cell culture, few vaccine studies using cell culture propagated PEDV have been performed on U.S. strains in pigs. Therefore, the objective of this study was to evaluate the humoral immune response to the selected inactivated PEDV vaccine candidate in a dose-titration manner. RESULTS: PEDV was isolated from a pig with diarrhea and complete genome sequencing found >99% nucleotide identity to other U.S. PEDV. Inactivated adjuvanted monovalent vaccines were administered intramuscularly to five week old pigs in a dose titration experimental design, ranging from 6.0-8.0 log(10) tissue culture infective dose (TCID(50)/mL), to evaluate immunogenicity using a fluorescent foci neutralization assay (FFN), fluorescent microsphere immunoassay (FMIA), and enzyme-linked immunosorbent assay (ELISA) on sera. Pigs vaccinated with 8.0 log(10) TCID(50)/mL inactivated virus showed significantly higher FFN titers as well as FMIA and ELISA values than 6.0 log(10) TCID(50)/mL vaccinates and the negative controls. CONCLUSIONS: These results demonstrate the immunogenicity of a PEDV inactivated viral vaccine with a U.S. strain via dose-titration. A future vaccination-challenge study would illustrate the efficacy of an inactivated vaccine and help evaluate protective FFN titers and ELISA and FMIA responses.
has issue date	2015-03-15(xsd:dateTime)
bibo:doi	10.1186/s12917-015-0357-1
bibo:pmid	25881296
has license	cc-by
sha1sum (hex)	72e1f47796b2283c03f3d7aa4f6044592f8c198d
schema:url	https://doi.org/10.1186/s12917-015-0357-1
resource representing a document's title	An inactivated vaccine made from a U.S. field isolate of porcine epidemic disease virus is immunogenic in pigs as demonstrated by a dose-titration
has PubMed Central identifier	PMC4404228
has PubMed identifier	25881296
schema:publication	BMC Vet Res
resource representing a document's body	covid:72e1f47796b2283c03f3d7aa4f6044592f8c198d#body_text
is schema:about of	named entity 'pig' named entity 'pigs' named entity 'ranging' named entity 'titration' named entity 'NEUTRALIZATION' named entity 'OLD' named entity 'ASSAY' covid:arg/72e1f47796b2283c03f3d7aa4f6044592f8c198d named entity 'VACCINE' named entity 'DOSE' named entity 'ADMINISTERED' named entity 'COMPLETE GENOME SEQUENCING' named entity 'WEEK' named entity 'INACTIVATED' named entity 'FLUORESCENT' named entity 'HAVE' named entity 'PORCINE EPIDEMIC DIARRHEA VIRUS' named entity 'SERA' named entity 'DETECTED' named entity 'CELL CULTURE' named entity 'FOUND' named entity 'TISSUE CULTURE' named entity 'STUDIES' named entity 'DIARRHEA' named entity 'NUCLEOTIDE' named entity 'TCID' named entity 'TITRATION' named entity 'HUMORAL IMMUNE RESPONSE' named entity 'STRAINS' named entity 'MICROSPHERE' named entity 'FOCI' named entity 'DIFFICULTY' named entity 'VALUES' named entity 'SWINE' named entity 'SELECTED' named entity 'U.S.' named entity 'RESULTS' named entity 'VACCINATED' named entity 'PERFORMED' named entity 'CAUSED' named entity 'EXPERIMENTAL DESIGN' named entity 'ELISA' named entity 'ENZYME-LINKED IMMUNOSORBENT ASSAY' named entity 'HIGHLY' named entity 'FFN' named entity 'NEGATIVE' named entity 'IDENTITY' named entity 'USING' named entity 'DUE TO' named entity 'GROWING' named entity 'ADJUVANTED' named entity 'IMMUNOASSAY' named entity 'INDUSTRY' named entity 'LOG' named entity 'VACCINES' named entity 'ISOLATING' named entity 'STUDY' named entity 'PIGS' named entity 'VACCINE CANDIDATE' named entity 'IMMUNOGENICITY' named entity 'OBJECTIVE' named entity 'RESPONSE TO' named entity 'BACKGROUND' named entity 'VIRUS' named entity 'PATHOGENIC' named entity 'PIG' named entity 'INFECTIVE DOSE' named entity 'EVALUATE' named entity 'ISOLATED' named entity 'CONTROLS' named entity 'U.S.' named entity 'dose' named entity 'objective' named entity 'log' named entity 'study' named entity 'propagated'

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