About: Two distinct immunopathological profiles in lungs of lethal COVID-19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Two distinct immunopathological profiles in lungs of lethal COVID-19
Creator	Barbareschi, Mattia Kirsten, D Menter, Thomas Moch, Holger Tzankov, Alexandar Cathomas, Gieri Ciani, Yari Demichelis, Francesca Frank, Angela Haslbauer, Jasmin Henkel, Maurice Hoyler, Thomas Junt, Tobias Kempf, Werner Koelzer, Viktor Mertz, Mertz, Kirsten Nienhold, Ronny Schwab, Nathalie Tolnay, Markus Willi, Niels Zsikla, Veronika
source	MedRxiv
abstract	Immune responses in lungs of Coronavirus Disease 2019 (COVID-19) are poorly characterized. We conducted transcriptomic, histologic and cellular profiling of post mortem COVID-19 and normal lung tissues. Two distinct immunopathological reaction patterns were identified. One pattern showed high expression of interferon stimulated genes (ISGs) and cytokines, high viral loads and limited pulmonary damage, the other pattern showed severely damaged lungs, low ISGs, low viral loads and abundant immune infiltrates. Distinct patterns of pulmonary COVID-19 immune responses correlated to hospitalization time and may guide treatment and vaccination approaches.
has issue date	2020-06-19(xsd:dateTime)
bibo:doi	10.1101/2020.06.17.20133637
has license	medrxiv
sha1sum (hex)	72f42b5e9e8b4e96b3e5dc4eb609c7a663587569
schema:url	https://doi.org/10.1101/2020.06.17.20133637
resource representing a document's title	Two distinct immunopathological profiles in lungs of lethal COVID-19
resource representing a document's body	covid:72f42b5e9e8b4e96b3e5dc4eb609c7a663587569#body_text
is schema:about of	named entity 'LOADS' named entity 'GUIDE' named entity 'COVID-19' named entity 'STIMULATED' named entity 'PATTERNS' named entity 'NORMAL LUNG' named entity 'DAMAGE' named entity 'CORRELATED' named entity 'time' named entity 'Two' named entity 'expression' named entity 'high' named entity 'conducted' named entity 'pulmonary' named entity 'lungs' named entity 'ISGs' named entity 'COVID-19' named entity 'cytoplasmic' named entity 'histologic' named entity 'peer review' named entity 'CCL3' named entity 'pathology' named entity 'fibrosis' named entity 'GZMB' named entity 'CD1D' named entity 'COVID' named entity 'HLA-DMB' named entity 'autopsies' named entity 'ISG' named entity 'HLA-DQA1' named entity 'AIF1' named entity 'ISG' named entity 'staining' named entity 'CD163' named entity 'peer review' named entity 'KIR2DL1' named entity 'cytokine' named entity 'lungs' named entity 'medRxiv' named entity 'IRF1' named entity 'GUSB' named entity 'CX3CR1' named entity 'diffuse alveolar damage' named entity 'TNF' named entity 'CD8+ T cells' named entity 'CDK1' named entity 'gene signature' named entity 'peer review' named entity 'Wilcoxon rank sum test' named entity 'neutrophils' named entity 'MPO' named entity 'IL7' named entity 'C10orf54' named entity 'gene expression' named entity 'ISG' named entity 'cytokine' named entity 'cytokine' named entity 'exudative' named entity 'pathogens' named entity 'GZMA' named entity 'correlation' named entity 'hemorrhage' named entity 'ISG' named entity 'IL22'

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