About: Antibody and cytokine responses in kittens during the development of feline infectious peritonitis (FIP)

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About: Antibody and cytokine responses in kittens during the development of feline infectious peritonitis (FIP) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antibody and cytokine responses in kittens during the development of feline infectious peritonitis (FIP)
Creator	Gunn-Moore, D Gruffydd-Jones, T Caney, S Harbour, D Helps, C
Source	Elsevier; Medline; PMC
abstract	Two recombinant FIPV spike proteins were assessed for their immunogenic properties in 8-week-old kittens, which were then challenged intranasally with FIPV 79-1146. Humoral responses were assessed by ELISA and serum neutralisation test. Changes in PBMC cytokine mRNA levels were detected by a reverse transcription, semiquantitative polymerase chain reaction assay (RT-sqPCR), assessing IL-2, IL-4, IL-6, IL-10, IL-12 and IFNγ. All of the kittens developed clinical signs typical of FIP, which were confirmed on gross post mortem examination. The recombinant proteins induced little or no specific antibody response prior to challenge, and failed to alter the course of disease compared to controls. One week after virus challenge, the stimulated PBMCs showed small increases in the expression of IL-6 and IFNγ mRNA, which correlated with a transient pyrexia. After this time expression of IL-6 mRNA remained unaltered but, as FIP developed, mRNA levels of IL-2, IL-4, IL-10, IL-12 and IFNγ became markedly depressed.
has issue date	1998-10-23(xsd:dateTime)
bibo:doi	10.1016/s0165-2427(98)00156-1
bibo:pmid	9839876
has license	no-cc
sha1sum (hex)	7302bedde2389f0be9817661a6ada104d1de7049
schema:url	https://doi.org/10.1016/s0165-2427%2898%2900156-1
resource representing a document's title	Antibody and cytokine responses in kittens during the development of feline infectious peritonitis (FIP)
has PubMed Central identifier	PMC7120021
has PubMed identifier	9839876
schema:publication	Vet Immunol Immunopathol
resource representing a document's body	covid:7302bedde2389f0be9817661a6ada104d1de7049#body_text
is schema:about of	named entity 'CYTOKINE ' named entity 'depressed' named entity 'PBMCs' named entity 'IL-12' named entity 'All' named entity 'DEVELOPMENT' named entity 'ANTIBODY' named entity 'POLYMERASE CHAIN REACTION ASSAY' named entity '1146' named entity 'DEPRESSED' named entity 'ANTIBODY RESPONSE' named entity 'IL-2' named entity 'TRANSIENT' named entity 'PROTEINS' named entity 'FAILED' named entity 'MARKEDLY' named entity 'ONE WEEK' named entity 'TEST' named entity 'SPIKE' named entity 'IFNG' named entity 'IL-10' named entity 'SMALL' named entity 'CONFIRMED' covid:arg/7302bedde2389f0be9817661a6ada104d1de7049 named entity 'RESPONSES' named entity 'IL-12' named entity 'DETECTED' named entity 'SERUM' named entity 'SPECIFIC ANTIBODY' named entity 'IL-6' named entity 'FELINE INFECTIOUS PERITONITIS' named entity 'THEIR' named entity 'RECOMBINANT' named entity 'VIRUS' named entity 'LEVELS' named entity 'CHALLENGE' named entity 'OLD' named entity '10%' named entity 'INDUCED' named entity 'ALTER' named entity 'CHANGES' named entity 'IMMUNOGENIC' named entity 'BUT' named entity 'MRNA' named entity 'PROPERTIES' named entity 'CYTOKINE ' named entity 'EXPRESSION' named entity 'ELISA' named entity 'FIP' named entity 'IL-4' named entity 'PRIOR TO' named entity 'RESPONSES' named entity 'ASSESSING' named entity 'FIPV' named entity 'INCREASES' named entity 'REVERSE TRANSCRIPTION' named entity 'TYPICAL' named entity 'LITTLE' named entity 'GROSS' named entity 'PYREXIA' named entity 'ASSESSED' named entity 'COMPARED' named entity 'STIMULATED' named entity 'DISEASE' named entity 'POST MORTEM EXAMINATION' named entity 'TIME' named entity 'COURSE' named entity 'PBMC' named entity 'RECOMBINANT PROTEINS' named entity 'UNALTERED' named entity 'CORRELATED' named entity 'levels' named entity 'spike' named entity 'IL-6' named entity 'IFNg' named entity 'levels' named entity 'assay'

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