About: Immune protection conferred by three commonly used commercial live attenuated vaccines against the prevalent local strains of avian infectious bronchitis virus in southern China

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About: Immune protection conferred by three commonly used commercial live attenuated vaccines against the prevalent local strains of avian infectious bronchitis virus in southern China Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Immune protection conferred by three commonly used commercial live attenuated vaccines against the prevalent local strains of avian infectious bronchitis virus in southern China
Creator	Mo, Mei-Lan Wei, Ping Huang, Teng Tang, Ning Fan, Wen-Sheng Wei, Tian-Chao He, Yi-Ning Zhang, Li-Hua Chen, Jian-Cai Li, He-Ming Wang, Hai-Yong Zhong, Lian
Source	Medline; PMC
abstract	Live attenuated vaccines are critical in the control of avian infectious bronchitis. It is necessary to know the protection conferred by commonly used commercial live vaccines. In this study, specific pathogen-free chicks were vaccinated with the commercial live vaccines H120, 4/91 and LDT3-A. Blood samples were collected at weekly intervals for the detection of IBV-specific antibodies and quantification of CD4(+) and CD8(+) T lymphocytes. At 21 days post-inoculation the vaccinated birds were challenged with the IBV prevalent local strains GX-YL5, GX-GL11079 and GX-NN09032, respectively. Trachea and kidney samples were collected at 5 days post-challenge for the detection of the virus. The results showed that the H120 group exhibited medium antibody levels, the lowest percentages of CD4(+), CD8(+) T lymphocytes and the highest viral loads. The 4/91 group showed the lowest antibody levels, but the highest percentages of CD4(+), CD8(+) T lymphocytes and the lowest viral loads. The LDT3-A group showed the highest antibody levels, the medium percentages of CD4(+), CD8(+) T lymphocytes and the medium viral loads. The protection rates of H120, 4/91 and LDT3-A groups were 41.7–58.3%, 75.0–83.7% and 66.7–75.0%, respectively. The present study demonstrated that the vaccines H120, 4/91 and LDT3-A could stimulate the immunized chicks to produce different levels of humoral and cellular immunity to resist the infection of IBV, but couldn’t provide complete protection against the prevalent local strains of IBV in southern China. Also, the vaccine 4/91 offered the best immune protection among the three vaccines.
has issue date	2018-07-18(xsd:dateTime)
bibo:doi	10.1292/jvms.18-0249
bibo:pmid	30022779
has license	cc-by-nc-nd
sha1sum (hex)	7307753da247144e66cc91b8f48c33e5a9ceff2b
schema:url	https://doi.org/10.1292/jvms.18-0249
resource representing a document's title	Immune protection conferred by three commonly used commercial live attenuated vaccines against the prevalent local strains of avian infectious bronchitis virus in southern China
has PubMed Central identifier	PMC6160892
has PubMed identifier	30022779
schema:publication	J Vet Med Sci
resource representing a document's body	covid:7307753da247144e66cc91b8f48c33e5a9ceff2b#body_text
is schema:about of	named entity 'KIDNEY' named entity 'IBV' named entity 'IMMUNE PROTECTION' named entity 'PROTECTION' named entity '66.7' named entity 'CD4' named entity 'FREE' named entity 'VIRAL' named entity 'WEEKLY' named entity 'CRITICAL' named entity 'STIMULATE' named entity 'SAMPLES' named entity 'VACCINE' named entity 'CELLULAR IMMUNITY' named entity 'VACCINATED' named entity 'AVIAN INFECTIOUS BRONCHITIS' named entity 'ATTENUATED VACCINES' named entity 'stimulate' named entity 'virus' named entity 'antibody' named entity 'LOADS' named entity 'LIVE' named entity 'PROVIDE' named entity 'DIFFERENT' named entity 'USED' named entity 'LOCAL' named entity 'ATTENUATED VACCINES' named entity 'COMMERCIAL' named entity 'CHICKS' named entity 'PATHOGEN' named entity 'SOUTHERN' named entity 'BLOOD SAMPLES' named entity 'LOCAL' named entity 'STRAINS' named entity 'LIVE' named entity 'BUT' named entity 'BEST' named entity 'IMMUNIZED' named entity 'ANTIBODY' named entity 'AVIAN INFECTIOUS BRONCHITIS VIRUS' named entity 'CHINA' named entity 'PREVALENT' named entity 'SOUTHERN' named entity 'STRAINS' named entity 'IMMUNE PROTECTION' named entity 'LEVELS' named entity 'MEDIUM' named entity 'COMPLETE' named entity 'QUANTIFICATION' named entity 'INFECTION' named entity 'RATES' named entity 'TO PRODUCE' named entity 'VIRUS' named entity 'LOWEST' named entity 'PREVALENT' named entity 'ANTIBODIES' named entity 'DAYS' named entity 'DETECTION' named entity 'BIRDS' named entity 'CHINA' named entity 'COMMERCIAL' named entity 'POST' named entity 'STUDY' named entity 'INTERVALS' named entity 'HIGHEST' named entity 'A GROUP' named entity 'OFFERED' named entity 'TRACHEA' named entity 'SPECIFIC' named entity 'RESULTS'

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