About: An octamer of enolase from Streptococcus suis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : wasabi.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An octamer of enolase from Streptococcus suis
Creator	Lu, Guangwen Qi, Jianxun Gao, George Lu, Qiong Lu, Hao
Source	PMC
abstract	Enolase is a conserved cytoplasmic metalloenzyme existing universally in both eukaryotic and prokaryotic cells. The enzyme can also locate on the cell surface and bind to plasminogen, via which contributing to the mucosal surface localization of the bacterial pathogens and assisting the invasion into the host cells. The functions of the eukaryotic enzymes on the cell surface expression (including T cells, B cells, neutrophils, monocytoes, neuronal cells and epithelial cells) are not known. Streptococcus suis serotype 2 (S. suis 2, SS2) is an important zoonotic pathogen which has recently caused two large-scale outbreaks in southern China with severe streptococcal toxic shock syndrome (STSS) never seen before in human sufferers. We recently identified the SS2 enolase as an important protective antigen which could protect mice from fatal S.suis 2 infection. In this study, a 2.4-angstrom structure of the SS2 enolase is solved, revealing an octameric arrangement in the crystal. We further demonstrated that the enzyme exists exclusively as an octamer in solution via a sedimentation assay. These results indicate that the octamer is the biological unit of SS2 enolase at least in vitro and most likely in vivo as well. This is, to our knowledge, the first comprehensive characterization of the SS2 enolase octamer both structurally and biophysically, and the second octamer enolase structure in addition to that of Streptococcus pneumoniae. We also investigated the plasminogen binding property of the SS2 enzyme.
has issue date	2012-10-01(xsd:dateTime)
bibo:doi	10.1007/s13238-012-2040-7
bibo:pmid	23055041
has license	gold-oa
sha1sum (hex)	7338d789573f5353a598c74270b7a0362df9603e
schema:url	https://doi.org/10.1007/s13238-012-2040-7
resource representing a document's title	An octamer of enolase from Streptococcus suis
has PubMed Central identifier	PMC4875344
has PubMed identifier	23055041
schema:publication	Protein & Cell
resource representing a document's body	covid:7338d789573f5353a598c74270b7a0362df9603e#body_text
is schema:about of	named entity 'ENOLASE' named entity 'vivo' named entity 'solution' named entity 'zoonotic' named entity 'sufferers' named entity 'mucosal surface' named entity 'invasion' named entity 'enolase' named entity 'investigated' named entity 'bacterial pathogens' named entity 'toxic shock syndrome' named entity 'HOST CELLS' named entity 'RECENTLY' named entity 'IN VIVO' named entity 'PROTECTIVE ANTIGEN ' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'CYTOPLASMIC' named entity 'NEUTROPHILS' named entity 'STREPTOCOCCUS SUIS SEROTYPE 2' named entity 'STREPTOCOCCAL TOXIC SHOCK SYNDROME' named entity 'ENZYMES' named entity 'UNIT' named entity 'ARRANGEMENT' named entity 'SCALE' named entity 'INVASION' named entity 'LARGE' named entity 'CELLS' named entity 'ENZYME' named entity 'SS2' named entity 'KNOWLEDGE' named entity 'RESULTS' named entity 'INVESTIGATED' named entity 'PROTEIN ' named entity 'MUCOSAL SURFACE' named entity 'IMPORTANT' named entity '2.4' named entity 'EUKARYOTIC' named entity 'SECOND' named entity 'STREPTOCOCCUS SUIS' named entity 'SEVERE' named entity 'IS A' named entity 'ANGSTROM' named entity 'ZOONOTIC PATHOGEN' named entity 'OUR' named entity 'STUDY' named entity 'CRYSTAL' named entity 'SEEN' named entity 'OUTBREAKS' named entity 'SEDIMENTATION' named entity 'CONTRIBUTING' named entity 'ASSAY' named entity 'PLASMINOGEN' named entity 'ASSISTING' named entity 'CHINA' named entity 'STRUCTURE' named entity 'SOLUTION' named entity 'CHARACTERIZATION' named entity 'BIND' named entity 'BIOLOGICAL' named entity 'CAUSED' named entity 'IN VITRO' named entity 'CELL' named entity 'FATAL' named entity 'COMPREHENSIVE' named entity 'CELL SURFACE' named entity 'METALLOENZYME' named entity 'BINDING' named entity 'ENOLASE' named entity 'NOT KNOWN' named entity '28S' named entity 'B CELLS' named entity 'REVEALING' named entity 'FUNCTIONS' named entity 'EPITHELIAL CELLS' named entity 'THE CELL' named entity 'CONSERVED' named entity 'BACTERIAL PATHOGENS'

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